Product image of Irbesartan Jubilant (Irbesartan) supplied by GNH India

Irbesartan Jubilant

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Jubilant (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Jubilant, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It selectively lowers elevated blood pressure and is indicated for the treatment of hypertension in adult patients.

GNH India supplies Irbesartan Jubilant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Clients benefit from reliable logistics and comprehensive documentation for import clearance.

Manufacturer / TM Owner

Jubilant Pharmaceuticals Nv

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Indications & Clinical Uses

  • Irbesartan acts on the renin‑angiotensin‑aldosterone system to control high blood pressure and related renal conditions.
  • Hypertension: reduces systolic and diastolic blood pressure, lowering cardiovascular risk.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Proteinuria associated with chronic kidney disease: decreases urinary protein excretion, supporting renal protection.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth muscle, adrenal gland, and renal tubular cells. By preventing angiotensin II binding, it inhibits vasoconstriction, aldosterone secretion, and sympathetic activation, leading to vasodilation, reduced sodium and water retention, and lowered systemic vascular resistance. The blockade also improves endothelial function and reduces cardiac remodeling over long‑term therapy.

Side Effects

Irbesartan may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Upper respiratory tract infection

Serious or Rare Side Effects

  • Angioedema
  • Hyperkalemia
  • Acute renal failure

Precautions & Warnings

  • When prescribing Irbesartan, clinicians should consider several safety measures.
  • Monitor blood pressure: adjust therapy based on regular measurements.
  • Assess renal function: check serum creatinine and eGFR before initiation and periodically.
  • Check electrolytes: especially potassium levels to detect hyperkalemia.
  • Avoid use in patients with severe hepatic impairment: limited data available.
  • Pregnancy: drug is contraindicated in the second and third trimesters due to fetal toxicity.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Irbesartan can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • ACE inhibitors or other ARBs: additive blood‑pressure lowering and renal effects.
  • Aliskiren in diabetic patients: increased risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and impair renal function.
  • Lithium: may increase serum lithium concentrations.
  • Cyclosporine or tacrolimus: may raise irbesartan plasma levels.

Frequently Asked Questions

Irbesartan Jubilant is prescribed to lower high blood pressure in adults and to protect kidney function in patients with diabetic nephropathy or proteinuric chronic kidney disease. By controlling hypertension, it helps reduce the risk of cardiovascular events and slows renal disease progression.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This results in relaxed blood vessels, reduced sodium and water retention, and lower systemic vascular resistance, which together lower blood pressure.

The appropriate dose of Irbesartan Jubilant is determined by the prescribing healthcare professional based on the patient’s blood‑pressure readings, renal function, and overall clinical profile. Dosage adjustments are made according to individual response and tolerability.

The safety of Irbesartan in pregnancy is not established and it is generally contraindicated in the second and third trimesters because of potential fetal toxicity. Limited data exist for breastfeeding; therefore, a risk‑benefit assessment by the clinician is required.

To place an order, submit an enquiry on the Irbesartan Jubilant product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, offering blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers, ARBs act on the renin‑angiotensin system rather than directly relaxing vascular smooth muscle, providing an alternative mechanism for patients who need combination therapy.

Store Irbesartan Jubilant at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Irbesartan Jubilant is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious adverse events include angioedema, severe hyperkalemia, and acute renal failure. Patients should seek immediate medical attention if they experience swelling of the face, lips or throat, unexplained muscle weakness, or a sudden decline in kidney function.

Irbesartan is contraindicated in patients with known hypersensitivity to the drug or any ARB, in those with severe hepatic impairment, and in pregnant women during the second and third trimesters. Caution is also advised for individuals with baseline hyperkalemia or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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