Product image of Irbesartan Medical Valley (Irbesartan) supplied by GNH India

Irbesartan Medical Valley

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Medical Valley (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Medical Valley, is an Angiotensin II receptor blocker (ARB) presented as an oral dosage form for oral use. It treats hypertension and diabetic nephropathy in adult patients.

GNH India supplies Irbesartan Medical Valley as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

  • Irbesartan belongs to the class of Angiotensin II receptor blockers and is used to manage conditions related to the renin‑angiotensin system.
  • Hypertension: lowers elevated blood pressure and reduces cardiovascular risk.
  • Diabetic nephropathy: slows the progression of kidney damage in patients with type 2 diabetes.

How It Works

  • Irbesartan selectively antagonizes the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from binding. This blocks vasoconstriction and aldosterone secretion, leading to vasodilation, reduced sodium and water retention, and ultimately lower blood pressure and decreased renal stress.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Fatigue.
  • Nausea.
  • Elevated potassium levels.
  • Mild hypotension.

Serious or Rare Side Effects

  • Angioedema or severe swelling.
  • Acute renal failure.
  • Hepatic injury.
  • Severe hypotension.
  • Allergic reactions such as rash or hives.
  • Hyperkalemia leading to cardiac arrhythmia.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure regularly to assess therapeutic response.
  • Check renal function and serum creatinine at baseline and periodically.
  • Monitor serum potassium, especially in patients on potassium‑sparing diuretics or supplements.
  • Use with caution in pregnancy; Irbesartan is classified as Category D.
  • Avoid in patients with severe hepatic impairment.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan may interact with several medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients.
  • Combination with ACE inhibitors or other ARBs (risk of hyperkalemia and renal impairment).
  • Use with potassium‑sparing diuretics (increased potassium levels).
  • Co‑administration with NSAIDs (potential renal function decline).

Moderate Interactions (Monitor Closely)

  • Lithium (increased lithium levels).
  • Other antihypertensives (additive blood pressure lowering).
  • Cyclosporine or tacrolimus (enhanced nephrotoxicity).

Frequently Asked Questions

Irbesartan Medical Valley is prescribed to lower high blood pressure and to slow the progression of kidney disease in adults with diabetic nephropathy. It belongs to the class of Angiotensin II receptor blockers, which act on the renin‑angiotensin system.

Irbesartan blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from causing vasoconstriction and aldosterone release. This results in relaxed blood vessels, reduced fluid retention, and lower blood pressure, while also protecting the kidneys from further damage.

The dose of Irbesartan Medical Valley is individualized by the prescribing clinician based on the patient’s condition, response, and renal function. Patients should follow the dosage instructions provided by their healthcare professional.

Irbesartan is classified as Pregnancy Category D, indicating potential risk to the fetus. It should be avoided during pregnancy. Limited data are available for breastfeeding; the decision to use it while nursing should be made by a physician after weighing benefits and risks.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Irbesartan, an ARB, offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough. Compared with calcium‑channel blockers or diuretics, it specifically targets the renin‑angiotensin pathway, making it useful for patients who also need renal protection.

Store Irbesartan Medical Valley at room temperature, below 25 °C, in the original packaging. Protect the product from moisture and direct sunlight to maintain its stability and potency.

Irbesartan Medical Valley is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless directed by a healthcare professional.

Serious risks include angioedema, severe hypotension, acute renal failure, hepatic injury, and hyperkalemia that can lead to cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, rapid weight gain, or persistent dizziness.

Irbesartan should be avoided in patients with known hypersensitivity to the drug, severe hepatic impairment, or in women who are pregnant. Caution is also advised for individuals with significant renal dysfunction or those taking other medications that raise potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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