Product image of Irbesartan Stada (Irbesartan) supplied by GNH India

Irbesartan Stada

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Stada (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Stada, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is employed to manage high blood pressure and to protect kidney function in patients with diabetic nephropathy.

GNH India supplies Irbesartan Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution. Customers benefit from reliable supply chains, comprehensive documentation, and responsive technical support.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Irbesartan acts on the renin‑angiotensin‑aldosterone system to lower blood pressure and protect renal function.
  • Hypertension: reduces systemic vascular resistance and lowers blood pressure.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Proteinuria in diabetic patients: decreases urinary protein excretion, contributing to renal protection.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth‑muscle cells, adrenal gland, and renal tubular cells. By preventing angiotensin II binding, it inhibits vasoconstriction, aldosterone secretion, and sympathetic activation, leading to reduced peripheral resistance, decreased sodium and water retention, and lowered blood pressure. The blockade also mitigates intraglomerular hypertension, providing renal protective effects.

Side Effects

Irbesartan may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Abdominal discomfort
  • Cough

Serious or Rare Side Effects

  • Angioedema (swelling of face, lips, tongue)
  • Severe hyperkalemia
  • Acute renal failure or worsening kidney function
  • Hepatic injury (elevated liver enzymes, jaundice)

Precautions & Warnings

  • When prescribing Irbesartan, clinicians should observe several safety considerations.
  • Monitor blood pressure: check regularly to ensure therapeutic effect.
  • Monitor renal function: assess serum creatinine and eGFR before and during therapy.
  • Monitor serum potassium: detect hyperkalemia, especially with potassium‑sparing agents.
  • Avoid use in pregnancy: drug is contraindicated due to fetal toxicity (Category D).
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients.
  • Dual therapy with ACE inhibitors or other ARBs.
  • Potassium‑sparing diuretics (e.g., spironolactone, amiloride).
  • Lithium (may increase serum levels).

Moderate Interactions (Monitor Closely)

  • NSAIDs (risk of renal impairment).
  • Thiazide diuretics (enhanced hypotensive effect).
  • Cyclosporine (may increase serum creatinine).
  • Rifampin (may reduce plasma concentration of Irbesartan).

Frequently Asked Questions

Irbesartan Stada is prescribed to lower high blood pressure (hypertension) and to protect kidney function in patients with diabetic nephropathy. By controlling blood pressure and reducing renal stress, it helps slow the progression of kidney disease associated with diabetes.

Irbesartan works by selectively blocking angiotensin II type 1 (AT1) receptors. This prevents angiotensin II from causing blood vessels to narrow and from stimulating aldosterone release, resulting in vasodilation, reduced sodium and water retention, and lower blood pressure, while also lessening pressure within the kidney’s filtering units.

The dose of Irbesartan Stada is individualized by the prescribing healthcare professional based on the patient’s blood pressure, kidney function, and overall clinical condition. The prescriber will determine the appropriate strength and frequency according to current treatment guidelines.

Irbesartan is classified as pregnancy Category D, indicating evidence of fetal risk and it is contraindicated during pregnancy. Limited data are available for breastfeeding; therefore, use is generally discouraged unless the potential benefit outweighs the risk. Women of child‑bearing potential should use effective contraception.

To order Irbesartan Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control comparable to ACE inhibitors but with a lower incidence of cough and angio‑edema. Unlike some diuretics, it does not cause electrolyte loss, and it provides additional renal protection in diabetic patients, making it a preferred option for those with kidney concerns.

Irbesartan Stada should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain stability and potency throughout the shelf life.

Irbesartan Stada is taken orally, usually as a whole tablet with or without food. Patients should swallow the tablet with a full glass of water and follow the dosing schedule prescribed by their healthcare provider.

The most serious risks include angio‑edema (swelling of the face, lips, tongue, or throat), severe hyperkalemia (elevated potassium levels), and acute renal failure or worsening kidney function. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, or sudden changes in kidney‑related lab values.

Irbesartan Stada should not be used by individuals who are pregnant, have known hypersensitivity to Irbesartan or any ARB component, or have severe hepatic impairment. Caution is also advised for patients with existing renal dysfunction, high potassium levels, or those taking interacting medications such as aliskiren in diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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