Product image of Irbesartan Stada (Irbesartan) supplied by GNH India

Irbesartan Stada

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Stada (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Stada, is an angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It lowers blood pressure and protects kidney function, and is used in patients with hypertension, diabetic kidney disease, or heart failure, often as part of a comprehensive cardiovascular management plan.

GNH India supplies Irbesartan Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Irbesartan is an angiotensin II receptor blocker indicated for several cardiovascular and renal conditions.

  • Hypertension: reduces systolic and diastolic blood pressure, helping patients reach target levels.
  • Diabetic nephropathy: slows progression of kidney damage in individuals with type 2 diabetes.
  • Heart failure: improves symptoms and lowers the risk of hospitalization in patients with reduced ejection fraction.

How It Works

  • Irbesartan selectively blocks the binding of angiotensin II to the AT1 receptors located on vascular smooth muscle, adrenal gland and renal tubular cells. By preventing this interaction, it inhibits vasoconstriction, aldosterone release, and sodium‑water retention, leading to vasodilation, reduced blood volume and lower blood pressure. Additionally, it reduces sympathetic nervous system activation, attenuating pathological remodeling in the heart and kidneys.

Side Effects

Irbesartan may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Diarrhea

Serious or Rare Side Effects

  • Hyperkalemia
  • Acute kidney injury
  • Angioedema
  • Severe hypotension

Precautions & Warnings

When prescribing Irbesartan, clinicians should observe several safety considerations.

  • Blood pressure monitoring: check for excessive hypotension after initiation or dose changes.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during therapy.
  • Serum potassium measurement: monitor for hyperkalemia, especially with concomitant potassium‑sparing agents.
  • Pregnancy warning: avoid use in pregnancy due to risk of fetal toxicity (Category D).
  • Drug interactions: review concomitant use of ACE inhibitors, aliskiren, or potassium supplements.
  • Store below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Irbesartan interacts with several medicines that can alter its efficacy or safety profile.

Major Interactions (Avoid)

  • ACE inhibitors or aliskiren in pregnancy: combined use can cause severe hypotension and fetal harm.
  • Potassium‑sparing diuretics (e.g., spironolactone): increase risk of hyperkalemia.
  • NSAIDs (e.g., ibuprofen): may reduce antihypertensive effect and impair renal function.
  • Lithium: increased lithium levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: additive blood pressure lowering may require dose adjustment.
  • CYP2C9 inhibitors (e.g., fluconazole): may raise Irbesartan plasma concentrations.
  • CYP3A4 inducers (e.g., rifampin): may lower Irbesartan levels, reducing efficacy.

Frequently Asked Questions

Irbesartan Stada contains the active ingredient Irbesartan, an angiotensin II receptor blocker that is prescribed to lower high blood pressure, slow kidney damage in diabetic patients, and improve outcomes in heart failure. It is part of a broader treatment plan for cardiovascular and renal health.

Irbesartan selectively blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction, aldosterone release, and sodium‑water retention. This leads to relaxed blood vessels, reduced blood volume, lower blood pressure, and decreased stress on the heart and kidneys.

The appropriate dose of Irbesartan Stada is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other medications. Patients should follow the dosing instructions provided by their healthcare professional.

Irbesartan is classified as Pregnancy Category D, indicating evidence of fetal risk. It should be avoided during pregnancy. Limited data are available for breastfeeding, and the drug may pass into breast milk; therefore, use is generally not recommended without medical advice.

To request Irbesartan Stada, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Irbesartan belongs to the ARB class, which blocks angiotensin II receptors, whereas ACE inhibitors block its production. Both lower blood pressure, but ARBs like Irbesartan are less likely to cause a persistent cough. Choice between them depends on patient tolerance, comorbidities, and physician preference.

Irbesartan Stada should be stored below 25 °C in its original packaging, protected from moisture and light. Do not store in a bathroom or near a heat source. Keep the container tightly closed and out of reach of children.

Irbesartan Stada is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

Serious risks include hyperkalemia (elevated potassium levels), acute kidney injury, severe hypotension, and rare cases of angioedema. Patients should be monitored for these conditions, especially when taking other drugs that affect potassium or renal function.

Irbesartan Stada should not be used by individuals with known hypersensitivity to Irbesartan or any ARB, pregnant women, or patients with severe hepatic impairment without medical supervision. Caution is also advised for those with significant renal impairment or high potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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