Product image of Irbesartan Tetrafarma (Irbesartan) supplied by GNH India

Irbesartan Tetrafarma

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Tetrafarma (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Tetrafarma, is an angiotensin II receptor blocker presented as an oral dosage form for oral use. Originating from the European Union market, it is employed to lower high blood pressure and to protect kidney function in patients with diabetic nephropathy. The product complies with EU regulatory requirements and is manufactured under strict quality controls.

GNH India supplies Irbesartan Tetrafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing standards and reliable distribution across global markets.

Manufacturer / TM Owner

Tetrafarma- Produtos Farmacêuticos, Lda.

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Indications & Clinical Uses

Irbesartan acts on the renin‑angiotensin‑aldosterone system to control blood pressure and renal disease progression.

  • Hypertension: Reduces systolic and diastolic blood pressure in patients with elevated readings.
  • Diabetic nephropathy: Slows the decline of kidney function in individuals with diabetes‑related kidney disease.
  • Chronic kidney disease associated with diabetes: Provides renal protection by decreasing proteinuria and preserving glomerular filtration rate.

How It Works

  • Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II‑mediated vasoconstriction, aldosterone secretion, and sympathetic activation. This antagonism leads to vasodilation, reduced sodium and water retention, and decreased blood pressure, while also mitigating renal fibrosis and proteinuria in diabetic kidney disease.

Side Effects

Common side effects are generally mild and reversible.

Common Side Effects

  • Dizziness: Light‑headed sensation, especially after standing.
  • Headache: Mild to moderate cranial discomfort.
  • Fatigue: Generalized tiredness without exertion.
  • Abdominal pain: Mild stomach discomfort.
  • Hyperkalemia: Elevated blood potassium levels.

Serious or Rare Side Effects

  • Angioedema: Swelling of face, lips, tongue, or airway.
  • Severe hypotension: Marked drop in blood pressure causing faintness.
  • Acute renal failure: Sudden loss of kidney function.
  • Hepatic injury: Elevated liver enzymes or hepatitis.

Precautions & Warnings

Patients should be monitored for safety and appropriate use.

  • Blood pressure monitoring: Check regularly to avoid excessive lowering.
  • Renal function assessment: Evaluate serum creatinine and eGFR before and during therapy.
  • Serum potassium measurement: Monitor for hyperkalemia, especially with concomitant potassium‑sparing agents.
  • Pregnancy and lactation: Use only if clearly needed; discuss risks with a healthcare professional.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Irbesartan may interact with several drug classes, requiring caution.

Major Interactions (Avoid)

  • ACE inhibitors: Combined use increases risk of hyperkalemia and renal impairment.
  • Aliskiren (in diabetes): May cause severe hypotension and renal dysfunction.
  • Potassium‑sparing diuretics: Heightens risk of dangerous hyperkalemia.
  • NSAIDs: Can reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Diuretics: May enhance initial blood pressure lowering; monitor electrolytes.
  • Lithium: Irbesartan can increase lithium levels; check serum concentrations.
  • Other antihypertensives: Additive blood pressure reduction; adjust doses as needed.
  • NSAIDs (monitor): May affect renal function; observe kidney markers.

Frequently Asked Questions

Irbesartan Tetrafarma contains the active ingredient Irbesartan, which is prescribed to lower high blood pressure and to protect kidney function in patients with diabetic nephropathy. It belongs to the angiotensin II receptor blocker class and works by blocking the effects of angiotensin II.

Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from causing vasoconstriction and aldosterone release. This results in blood vessel relaxation, reduced sodium and water retention, lower blood pressure, and decreased progression of kidney damage in diabetes.

The appropriate dose of Irbesartan Tetrafarma is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosing instructions provided by their healthcare professional and not adjust the dose on their own.

Irbesartan is generally not recommended during pregnancy because it may affect fetal development. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments with their healthcare provider to ensure safety for both mother and child.

To order Irbesartan Tetrafarma, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough. Compared with calcium‑channel blockers or diuretics, ARBs provide a distinct mechanism by blocking angiotensin II receptors, making them useful when other classes are not tolerated.

Irbesartan Tetrafarma should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid exposure to direct sunlight or extreme heat to maintain its stability and potency.

Irbesartan Tetrafarma is taken orally, usually with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a prescriber.

The most serious risks include angioedema (swelling of the face, lips, tongue, or airway), severe hypotension, acute renal failure, and hyperkalemia (elevated potassium levels). Patients should seek immediate medical attention if they experience symptoms such as swelling, faintness, or rapid changes in kidney function.

Irbesartan Tetrafarma should be avoided in individuals with known hypersensitivity to Irbesartan or any ARB component, those with severe hepatic impairment, and patients who are pregnant unless the benefits outweigh the risks. It should also be used with caution in patients with existing kidney disease or high potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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