Product image of Irbesartan Unichem (Irbesartan) supplied by GNH India

Irbesartan Unichem

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Unichem (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Unichem, is an angiotensin II receptor blocker presented as a tablet for oral use. It is used to manage high blood pressure and protect kidney function in certain diabetic patients.
GNH India supplies Irbesartan Unichem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Unichem Laboratories Limited

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Indications & Clinical Uses

Irbesartan is an angiotensin II receptor blocker that acts on the renin‑angiotensin system to lower blood pressure and reduce renal stress.

  • Hypertension: helps achieve target blood pressure levels in adults.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes and proteinuria.

How It Works

  • Irbesartan selectively antagonizes the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from binding. This inhibition blocks vasoconstriction, aldosterone secretion, and sympathetic activation, resulting in vasodilation, reduced sodium and water retention, and lower blood pressure. The drug’s action also diminishes intraglomerular pressure, offering renal protective effects in diabetic nephropathy.

Side Effects

Common Side Effects

  • Dizziness: feeling light‑headed, especially after standing.
  • Headache: mild to moderate intensity.
  • Fatigue: general tiredness or lack of energy.
  • Hyperkalemia: elevated potassium levels in blood tests.
  • Increased serum creatinine: modest rise indicating altered kidney function.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat requiring emergency care.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Acute renal failure: sudden loss of kidney function.
  • Hepatic injury: signs of liver damage such as jaundice.
  • Neutropenia: dangerously low white‑blood‑cell count.

Precautions & Warnings

Before starting Irbesartan, patients should be evaluated for renal function, electrolyte balance, and pregnancy status.

  • Monitor blood pressure: adjust dose to maintain target levels.
  • Check renal function: periodic serum creatinine and eGFR assessments.
  • Assess serum potassium: avoid hyperkalemia, especially with potassium‑sparing agents.
  • Contraindicated in pregnancy: risk of fetal toxicity; discontinue if pregnancy is confirmed.
  • Use caution in hepatic impairment: dose may need adjustment.
  • Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • ACE inhibitors or aliskiren: combined use can cause excessive potassium rise and renal impairment.
  • Potassium‑sparing diuretics: increase risk of hyperkalemia.
  • Lithium: may raise lithium concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely):\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): can diminish antihypertensive effect and affect kidney function.

  • CYP2C9 inhibitors (e.g., fluconazole): may increase Irbesartan plasma levels.
  • CYP2C9 inducers (e.g., rifampin): may reduce drug exposure.
  • Other antihypertensives: additive blood‑pressure lowering effect, monitor for hypotension.

Frequently Asked Questions

Irbesartan Unichem is prescribed to lower high blood pressure (hypertension) and to slow the progression of kidney damage in adults with type 2 diabetes who have proteinuria, a condition known as diabetic nephropathy. It works by blocking the effects of angiotensin II, a hormone that narrows blood vessels and raises blood pressure.

Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from causing vasoconstriction and aldosterone release. This leads to relaxation of blood vessels, reduced sodium and water retention, and lower blood pressure. The reduced intraglomerular pressure also helps protect kidney function in diabetic patients.

The specific dose of Irbesartan Unichem is determined by the prescribing healthcare professional based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Irbesartan is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be discontinued as soon as pregnancy is confirmed. Limited data are available for breastfeeding; therefore, the drug is generally not recommended for nursing mothers unless the potential benefit justifies the risk.

To order Irbesartan Unichem, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Irbesartan belongs to the angiotensin II receptor blocker (ARB) class, which offers similar blood‑pressure‑lowering effects as ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers or diuretics, ARBs provide a distinct mechanism focused on the renin‑angiotensin system, making them useful in patients who need renal protection.

Irbesartan Unichem tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Irbesartan Unichem is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not crush or chew the tablet unless specifically instructed.

The most serious risks include angioedema (swelling of the face, lips, tongue, or throat), severe hypotension, acute renal failure, and significant hyperkalemia. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, sudden dizziness, or a marked drop in urine output.

Irbesartan Unichem should not be used by individuals who are pregnant, have known hypersensitivity to Irbesartan or any ARB, or have severe hepatic impairment without medical supervision. Patients with a history of angioedema related to previous ARB or ACE‑inhibitor therapy should also avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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