Product image of Irbesartan Xiromed (Irbesartan) supplied by GNH India

Irbesartan Xiromed

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Xiromed (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Xiromed, is an angiotensin II receptor blocker (ARB) presented as an oral tablet for systemic use. It lowers blood pressure and reduces cardiovascular risk in adults with hypertension, diabetic kidney disease, or other related conditions.

GNH India supplies Irbesartan Xiromed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Customers benefit from reliable supply chains and professional technical support.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

  • Irbesartan is used to manage conditions related to the renin‑angiotensin system, primarily hypertension and its complications.
  • Hypertension: reduces systolic and diastolic blood pressure, helping achieve target levels.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Cardiovascular risk reduction: lowers the risk of stroke, myocardial infarction, and other major cardiovascular events.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth muscle, adrenal gland, and renal tubular cells. By preventing angiotensin II binding, it inhibits vasoconstriction, aldosterone secretion, and sympathetic activation, leading to vasodilation, reduced sodium and water retention, and ultimately lower arterial pressure. The blockade also mitigates pathological remodeling of the heart and kidneys associated with chronic activation of the renin‑angiotensin system.

Side Effects

Irbesartan may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Abdominal discomfort
  • Back pain

Serious or Rare Side Effects

  • Angioedema
  • Severe hypotension
  • Acute renal impairment
  • Hyperkalemia
  • Hepatic injury
  • Neutropenia

Precautions & Warnings

  • When prescribing Irbesartan, clinicians should consider several precautionary measures to ensure safe use.
  • Renal function: assess baseline renal function and monitor periodically.
  • Electrolytes: monitor serum potassium, especially in patients with renal impairment or on potassium‑sparing diuretics.
  • Pregnancy: avoid use in the second and third trimesters due to risk of fetal toxicity.
  • Concomitant drugs: adjust dose when combined with strong CYP2C9 inhibitors.
  • Hypotension: caution in volume‑depleted patients; monitor blood pressure after initiation.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Irbesartan can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalemia.
  • Aliskiren (in diabetic patients): increased risk of renal dysfunction, hypotension, hyperkalemia.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): may raise irbesartan plasma levels.
  • Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs): risk of renal impairment and hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive effect and affect renal function.
  • Lithium: may increase lithium levels, risk of toxicity.
  • Diuretics (loop or thiazide): may enhance hypotensive effect.

Frequently Asked Questions

Irbesartan Xiromed is prescribed to lower high blood pressure, to slow the progression of kidney disease in patients with type 2 diabetes, and to reduce the overall risk of cardiovascular events such as stroke or heart attack.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing blood vessels to narrow and the adrenal glands to release aldosterone. This results in vasodilation, reduced fluid retention, and lower arterial pressure.

The appropriate dose of Irbesartan Xiromed is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and any concomitant medications.

Irbesartan is generally contraindicated during the second and third trimesters of pregnancy because it may cause fetal toxicity. Safety during breastfeeding has not been established, so a risk‑benefit assessment is required.

To order, submit an enquiry on the Irbesartan Xiromed product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, offering blood‑pressure control comparable to ACE inhibitors but with a lower incidence of cough. It is often chosen when patients cannot tolerate ACE inhibitors or when additional renal protection is desired.

Store the tablets at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Keep out of reach of children.

Irbesartan Xiromed is taken orally, usually once daily, with or without food, as directed by the prescribing clinician.

Serious risks include angioedema, severe hypotension, acute kidney injury, and hyperkalemia. Patients should be monitored for signs of swelling, sudden drops in blood pressure, changes in renal function, or elevated potassium levels.

Irbesartan should be avoided in patients with known hypersensitivity to the drug, those in the second or third trimester of pregnancy, and individuals with severe hepatic impairment or uncontrolled hyperkalemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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