Product image of Irbesartan Zentiva (Irbesartan) supplied by GNH India

Irbesartan Zentiva

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Zentiva (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Zentiva, is an angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is employed to lower high blood pressure and to protect kidney function in patients with diabetic kidney disease.
GNH India supplies Irbesartan Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Irbesartan acts on the renin‑angiotensin‑aldosterone system to manage cardiovascular and renal conditions.

  • Hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Proteinuria in diabetic kidney disease: reduces urinary protein excretion, supporting renal preservation.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing angiotensin II‑mediated vasoconstriction, aldosterone release, and sympathetic activation. This results in vasodilation, reduced sodium and water retention, and decreased blood pressure, while also attenuating pathological remodeling in the kidneys and heart.

Side Effects

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: feeling unusually tired or weak.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat that may impair breathing.
  • Hyperkalemia: elevated blood potassium levels that can affect heart rhythm.
  • Acute renal failure: sudden loss of kidney function requiring medical attention.

Precautions & Warnings

Irbesartan should be used with careful clinical monitoring.

  • Blood pressure monitoring: check regularly to ensure therapeutic control.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during therapy.
  • Serum potassium: monitor for hyperkalemia, especially with potassium‑sparing agents.
  • Hepatic impairment: use cautiously; dose adjustment may be required.
  • Pregnancy: avoid use; potential fetal harm is unknown.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Irbesartan can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): combined use may increase renal risk.
  • Dual ARB/ACE inhibitor therapy: heightened risk of hypotension and kidney injury.
  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Lithium: increased lithium levels, monitor serum concentrations.
  • Rifampin: may reduce irbesartan plasma concentrations, adjust dose if needed.
  • NSAIDs: can diminish antihypertensive effect and impair renal function.

Frequently Asked Questions

Irbesartan Zentiva is prescribed to treat high blood pressure (hypertension) and to slow the progression of kidney disease in patients with type 2 diabetes, particularly when proteinuria is present. It works by relaxing blood vessels and reducing strain on the kidneys.

Irbesartan blocks angiotensin II type 1 (AT1) receptors, which prevents the hormone angiotensin II from causing blood vessels to narrow and from stimulating aldosterone release. This leads to vasodilation, lower blood pressure, and reduced stress on the kidneys.

The appropriate dose of Irbesartan Zentiva is determined by the prescribing healthcare professional based on the patient’s blood pressure, kidney function, and overall health status. Patients should follow the exact regimen provided by their prescriber.

Irbesartan is classified as contraindicated in pregnancy because it may harm the developing fetus. Safety during breastfeeding has not been established, so the drug should be avoided unless the benefits clearly outweigh the risks and a physician advises otherwise.

To order Irbesartan Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers, ARBs primarily target the renin‑angiotensin system, providing additional renal protective benefits in diabetic patients.

Irbesartan Zentiva tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use after the expiration date.

Irbesartan Zentiva is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

The most serious risks include angioedema, which can cause swelling of the face or throat and impair breathing, severe hyperkalemia that may affect heart rhythm, and acute renal failure, especially when combined with other drugs that affect kidney function.

Irbesartan should not be used by individuals with known hypersensitivity to irbesartan or any ARB components, pregnant women, or patients with severe hepatic impairment. Caution is also advised for those with existing kidney disease or elevated potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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