Product image of Iretig (Mirabegron) supplied by GNH India

Iretig

Active Ingredient:
Mirabegron
Origin:
EU

Iretig (Mirabegron)

Mirabegron, the active ingredient in Iretig, is a β3‑adrenergic receptor agonist presented as an oral tablet for oral use. It is indicated for the treatment of overactive bladder symptoms such as urinary urgency, frequency, and urge urinary incontinence in adults.

GNH India supplies Iretig as a licensed, GDP‑compliant international pharmaceutical product, providing reliable supply to hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across EU and global markets.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Mirabegron is used to manage symptoms of overactive bladder, a condition characterized by involuntary bladder contractions.

  • Overactive bladder: improves bladder storage capacity and reduces urgency episodes.
  • Urinary urgency: lessens the frequency of sudden urges to void.
  • Urge urinary incontinence: decreases episodes of involuntary leakage.

How It Works

  • Mirabegron selectively stimulates β3‑adrenergic receptors located in the detrusor smooth muscle of the bladder. Activation of these receptors raises cyclic AMP levels, causing relaxation of the detrusor during the storage phase, which expands bladder capacity and reduces involuntary contractions.

Side Effects

Adverse reactions reported with Mirabegron include:

Common Side Effects

  • Hypertension: elevated blood pressure.
  • Nasopharyngitis: inflammation of the nasal passages and throat.
  • Urinary tract infection: bacterial infection of the urinary system.
  • Headache: mild to moderate head pain.
  • Constipation: reduced bowel movements.
  • Dry mouth: decreased salivation.

Serious or Rare Side Effects

  • Angioedema: swelling of deep skin layers.
  • Severe hypertension: markedly high blood pressure.
  • Urinary retention: difficulty emptying the bladder.
  • Tachycardia: rapid heart rate.
  • Allergic reactions: rash, itching, or hives.
  • Hepatic injury: liver function abnormalities.

Precautions & Warnings

When prescribing Mirabegron, clinicians should consider several safety aspects.

  • Renal impairment: assess renal function before initiating therapy.
  • Hepatic impairment: monitor liver function tests during treatment.
  • Hypertension: check blood pressure regularly and manage elevations.
  • Drug interactions: review concomitant medications for potential interactions.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Mirabegron may interact with other medicines; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase Mirabegron exposure.
  • Antimuscarinic agents: additive anticholinergic effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce antihypertensive effect.
  • Nitrates: potential additive blood pressure effects.
  • Warfarin: monitor INR for anticoagulation changes.

Frequently Asked Questions

Iretig, containing Mirabegron, is prescribed for adults with overactive bladder, specifically to reduce urinary urgency, frequency, and episodes of urge urinary incontinence. It helps improve bladder storage capacity and control.

Mirabegron selectively activates β3‑adrenergic receptors in the bladder’s detrusor muscle. This activation raises cyclic AMP, leading to muscle relaxation during the storage phase, which increases bladder capacity and lessens involuntary contractions.

The appropriate dose of Iretig is determined by the prescribing healthcare professional based on individual patient factors. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety of Mirabegron in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To request Iretig, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) than antimuscarinics. It offers an alternative mechanism that may be better tolerated for patients who experience anticholinergic side effects such as dry mouth or constipation, though individual response varies.

Iretig should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and discard any product that appears damaged.

Iretig is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew it.

Serious risks include severe hypertension, angioedema, urinary retention, tachycardia, and rare liver injury. Patients should be monitored for sudden increases in blood pressure, swelling, difficulty urinating, rapid heart rate, or signs of liver dysfunction.

Iretig is contraindicated in patients with known hypersensitivity to Mirabegron or any of its excipients. Caution is advised for individuals with uncontrolled hypertension, severe hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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