Product image of Irexime (Clindamycin, Benzoyl Peroxide) supplied by GNH India

Irexime

Active Ingredient:
Clindamycin, Benzoyl Peroxide
Origin:
EU

Irexime (Clindamycin, Benzoyl Peroxide)

Clindamycin and Benzoyl Peroxide, the active ingredients in Irexime, are an antibiotic and keratolytic presented as a topical formulation for skin use. It treats acne vulgaris in adolescents and adults by reducing bacterial growth and inflammation.

GNH India supplies Irexime as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Irexime is a topical combination that targets the bacterial and inflammatory pathways of acne vulgaris.

  • Acne vulgaris: reduces inflammatory lesions and comedones, improving overall skin appearance.
  • Inflammatory acne: decreases Propionibacterium acnes colonisation and associated redness.
  • Non‑inflammatory acne (blackheads and whiteheads): helps unclog pores and prevent new lesions.

How It Works

  • Clindamycin binds to the 50S ribosomal subunit of Propionibacterium acnes, inhibiting protein synthesis and bacterial growth. Benzoyl peroxide decomposes to release oxygen free radicals that exert a bactericidal effect and reduce inflammation, while also promoting keratolysis to prevent pore blockage.

Side Effects

Irexime may cause local skin reactions, most of which are mild and transient.

Common Side Effects

  • Dryness or peeling of the treated area.
  • Mild erythema or redness.
  • Itching or burning sensation.
  • Tingling or stinging at application site.

Serious or Rare Side Effects

  • Severe contact dermatitis or allergic reaction.
  • Extensive skin irritation or ulceration.
  • Unusual swelling or bullae formation.

Precautions & Warnings

Before using Irexime, consider the following safety measures.

  • Avoid excessive sun exposure: use sunscreen and protective clothing.
  • Do not apply to broken or irritated skin: may increase irritation.
  • Limit use to prescribed area: avoid eyes, mucous membranes and open wounds.
  • Monitor for allergic reaction: discontinue and seek medical advice if severe rash develops.
  • Store at below 25°C: keep in the original container, protect from moisture and heat.

Avoid Interactions

Irexime can interact with other topical or systemic agents; awareness helps minimise adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with topical retinoids: may increase skin irritation.
  • Use with other antibacterial skin products: risk of excessive dryness.

Moderate Interactions (Monitor Closely)

  • Oral antibiotics (e.g., tetracyclines): may alter gut flora.
  • Alcohol‑based skin cleansers: may enhance dryness.
  • Photosensitising agents: increase sun sensitivity.

Frequently Asked Questions

Irexime is a topical combination of clindamycin and benzoyl peroxide indicated for the treatment of acne vulgaris. It targets both the bacterial component and the inflammatory process that contribute to the formation of pimples, blackheads, and whiteheads, helping to clear existing lesions and prevent new ones.

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of Propionibacterium acnes. This action stops the bacteria from multiplying, reducing the bacterial load on the skin and consequently decreasing inflammation associated with acne lesions.

The dosage regimen for Irexime is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected skin once or twice daily, but the exact frequency and duration depend on the severity of acne and the patient’s response to therapy.

Safety data for clindamycin and benzoyl peroxide in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Irexime.

To order Irexime, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Irexime combines an antibiotic (clindamycin) with a keratolytic (benzoyl peroxide), offering both antibacterial and comedolytic actions in a single product. Compared with monotherapy options such as topical retinoids or oral antibiotics, the combination can provide faster lesion reduction and lower the risk of antibiotic resistance when used as directed.

Store Irexime at temperatures below 25 °C in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Proper storage helps maintain product stability and efficacy.

Apply a thin, even layer of Irexime to clean, dry skin on the affected areas, usually once or twice daily as prescribed. Wash hands before and after application, and avoid contact with eyes, lips and mucous membranes. Do not cover the treated skin with occlusive dressings unless instructed by a clinician.

Serious adverse reactions, although rare, include severe contact dermatitis, extensive skin irritation, and allergic responses such as swelling, blistering or urticaria. If any of these occur, discontinue use immediately and seek medical attention.

Irexime should be avoided by individuals with known hypersensitivity to clindamycin, benzoyl peroxide, or any component of the formulation. It is also contraindicated on severely damaged, inflamed or infected skin, and should not be used on the face of patients with a history of severe allergic reactions to similar topical agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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