Product image of Irgass (Bromfenac) supplied by GNH India

Irgass

Active Ingredient:
Bromfenac
Origin:
EU

Irgass (Bromfenac)

Bromfenac, the active ingredient in Irgass, is a nonsteroidal anti‑inflammatory drug presented as an ophthalmic solution for ocular use. It is indicated for the treatment of post‑operative inflammation and pain following eye surgery as well as for managing general ocular inflammation. The formulation provides rapid ocular absorption, helping to reduce discomfort and swelling quickly.

GNH India supplies Irgass as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company ensures quality assurance and regulatory compliance across all shipments.

Manufacturer / TM Owner

Fb Vision S.P.A

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Indications & Clinical Uses

  • Bromfenac is an NSAID used to manage ocular inflammation.
  • Post‑operative inflammation and pain after ocular surgery: reduces swelling and discomfort, facilitating faster visual recovery.
  • Ocular inflammation: alleviates redness, edema, and pain associated with inflammatory eye conditions.
  • Ocular pain: provides rapid relief of discomfort caused by various eye irritations.

How It Works

  • Bromfenac inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues, blocking the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces inflammatory mediators that cause vasodilation, increased vascular permeability, and pain signaling in the eye. The localized inhibition within the anterior segment leads to diminished cellular infiltration and edema, providing anti‑inflammatory and analgesic effects without significant systemic exposure.

Side Effects

Bromfenac ophthalmic solution may cause ocular adverse reactions, ranging from mild irritation to rare serious events.

Common Side Effects

  • Eye irritation
  • Redness
  • Foreign body sensation
  • Tearing

Serious or Rare Side Effects

  • Corneal ulceration
  • Increased intraocular pressure
  • Severe allergic reaction (e.g., angioedema)
  • Vision loss

Precautions & Warnings

When prescribing bromfenac ophthalmic solution, several precautions should be observed to ensure patient safety.

  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion; consider discontinuation or monitor infant.
  • Concomitant ocular infection: assess risk of worsening infection before use.
  • Known hypersensitivity to bromfenac or other NSAIDs: contraindicated due to risk of allergic reactions.
  • Contact lens wearers: may experience increased irritation; advise removal during treatment.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Bromfenac may interact with other medications, affecting ocular or systemic safety.

Major Interactions (Avoid)

  • Systemic NSAIDs: additive risk of systemic adverse effects such as bleeding.
  • Anticoagulants (e.g., warfarin): potential for increased ocular bleeding.
  • Corticosteroid eye drops: may delay wound healing when used together.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: possible alteration of intraocular pressure control.
  • Other ophthalmic agents (e.g., mydriatics): monitor for additive irritation.

Frequently Asked Questions

Irgass contains bromfenac, an ophthalmic NSAID indicated for the treatment of post‑operative inflammation and pain after eye surgery and for managing general ocular inflammation. It helps reduce swelling, redness, and discomfort in the treated eye.

Bromfenac works by inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues, which blocks the formation of prostaglandins. Lower prostaglandin levels reduce inflammation, vascular permeability, and pain signaling within the eye.

The specific dosing regimen for Irgass is determined by the prescribing eye care professional based on the patient’s condition and response. Typically, a single drop is instilled in the affected eye as directed, but the exact frequency and duration are set by the clinician.

Safety data for bromfenac ophthalmic solution in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and clinicians usually advise caution or alternative therapy.

To order Irgass, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irgass (bromfenac) is similar to other ophthalmic NSAIDs such as nepafenac, offering potent anti‑inflammatory and analgesic effects with once‑daily dosing in many cases. Compared with steroid eye drops, bromfenac carries a lower risk of raising intraocular pressure but may be less effective for severe uveitis.

Irgass should be stored at room temperature, ideally below 25 °C, in its original container. Protect the solution from direct light and moisture, and keep the cap tightly closed when not in use to maintain sterility.

Irgass is administered as an ophthalmic solution. The patient instills the prescribed number of drops into the affected eye(s) using the provided dropper, typically avoiding contact between the tip and the eye or any surface to maintain sterility.

Serious risks, although rare, include corneal ulceration, a significant increase in intraocular pressure, severe allergic reactions such as angioedema, and potential vision loss. Patients should report any sudden worsening of vision, intense eye pain, or signs of infection promptly.

Irgass should not be used by individuals with a known hypersensitivity to bromfenac, other NSAIDs, or any component of the formulation. It is also contraindicated in patients with active ocular infections that could be aggravated by NSAID therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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