Product image of Irinotecan Hcl Aqvida Gmbh (Irinotecan Hydrochloride) supplied by GNH India

Irinotecan Hcl Aqvida Gmbh

Active Ingredient:
Irinotecan Hydrochloride
Origin:
EU

Irinotecan Hcl Aqvida Gmbh (Irinotecan Hydrochloride)

Irinotecan Hydrochloride, the active ingredient in Irinotecan Hcl Aqvida Gmbh, is a topoisomerase I inhibitor presented as an injectable solution for intravenous use. It is employed in the treatment of metastatic colorectal cancer in adult patients.
GNH India supplies Irinotecan Hcl Aqvida Gmbh as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Aqvida Gmbh

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Indications & Clinical Uses

  • Irinotecan Hydrochloride is a chemotherapy agent used primarily in the colorectal cancer treatment pathway.
  • Metastatic colorectal cancer: improves survival outcomes when incorporated into standard combination chemotherapy regimens.

How It Works

  • Irinotecan Hydrochloride is a pro‑drug that is converted intracellularly to SN‑38, a potent inhibitor of topoisomerase I. By stabilizing the DNA‑topoisomerase I complex, it prevents the relegation of single‑strand DNA breaks during replication, leading to accumulation of DNA damage and ultimately tumor cell death.

Side Effects

Irinotecan Hydrochloride may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting
  • Diarrhea (often early‑onset)
  • Neutropenia
  • Fatigue
  • Alopecia
  • Mild abdominal cramping

Serious or Rare Side Effects

  • Severe (late‑onset) diarrhea and colitis
  • Febrile neutropenia
  • Hepatic toxicity

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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