Product image of Irireact (Pheniramine Maleate, Tetryzoline Hydrochloride) supplied by GNH India

Irireact

Active Ingredient:
Pheniramine Maleate, Tetryzoline Hydrochloride
Origin:
EU

Irireact (Pheniramine Maleate, Tetryzoline Hydrochloride)

Pheniramine maleate / tetryzoline hydrochloride, the active ingredient in Irireact, is an Antihistamine and alpha‑adrenergic agonist presented as eye drops for ocular use. It relieves allergic conjunctivitis, eye itching and redness in adults and children.
GNH India supplies Irireact as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Montefarmaco Otc S.P.A.

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Indications & Clinical Uses

Irireact acts on ocular allergic pathways to reduce inflammation and vasodilation.

  • Allergic conjunctivitis: diminishes itching, tearing and redness caused by allergens.
  • Eye itching: provides rapid relief of itch sensations in the conjunctiva.
  • Redness of the eye: constricts conjunctival vessels to lessen visible redness.

How It Works

  • Pheniramine maleate blocks H1 histamine receptors on ocular mast cells, preventing histamine‑mediated inflammation. Tetryzoline hydrochloride stimulates alpha‑adrenergic receptors on conjunctival blood vessels, causing vasoconstriction that reduces hyperemia and swelling. The combined actions decrease allergic symptoms and improve ocular comfort.

Side Effects

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Transient blurred vision.
  • Mild eye irritation or dryness.
  • Temporary increased redness.
  • Mild headache.
  • Slight eye discomfort with contact lens use.

Serious or Rare Side Effects

  • Severe ocular irritation or allergic reaction.
  • Corneal ulceration or keratitis.
  • Significant increase in intra‑ocular pressure.
  • Systemic hypersensitivity (rash, swelling).
  • Anaphylactic reaction.
  • Persistent visual disturbances.

Precautions & Warnings

Use Irireact only as directed by a qualified eye‑care professional.

  • Hypersensitivity: avoid if known allergy to pheniramine, tetryzoline or excipients.
  • Glaucoma: use with caution; monitor intra‑ocular pressure.
  • Prolonged use: limit to short‑term relief; consult a clinician if symptoms persist beyond 7 days.
  • Contact lenses: remove lenses before application and wait several minutes before reinserting.
  • Pediatric use: follow pediatric guidance; avoid in infants unless advised.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Irireact may interact with other medications that affect vascular tone or histamine pathways.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (risk of hypertensive episodes).
  • Systemic decongestants or other ocular vasoconstrictors (excessive vasoconstriction).
  • Other topical antihistamines (additive ocular irritation).

Moderate Interactions (Monitor Closely)

  • Alcohol (may increase ocular dryness).
  • Beta‑blocker eye drops (potential additive effect on intra‑ocular pressure).
  • Multiple antihistamine products (monitor for cumulative sedation or irritation).

Frequently Asked Questions

Irireact is an over‑the‑counter eye‑drop formulation that combines an antihistamine with a vasoconstrictor to relieve symptoms of allergic conjunctivitis, including eye itching, redness, and watery discharge.

Pheniramine maleate blocks H1 histamine receptors on ocular mast cells, preventing histamine‑induced inflammation and itching. This reduces the allergic response that causes discomfort and tearing.

The dosing regimen for Irireact is determined by the prescribing eye‑care professional. Typically, one or two drops are instilled in the affected eye(s) as needed, but the exact frequency should follow the clinician’s instructions.

Safety data for pheniramine maleate and tetryzoline in pregnancy or lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider before using Irireact.

To order Irireact, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irireact combines an antihistamine (pheniramine) with a vasoconstrictor (tetryzoline), offering both anti‑inflammatory and decongestant effects. Alternative products may contain only an antihistamine or only a decongestant, which can be less effective for simultaneous itching and redness.

Irireact should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct sunlight, and avoid moisture to maintain product stability.

Irireact is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Close the eye gently and avoid blinking excessively.

Serious risks include severe ocular irritation, corneal ulceration, significant rise in intra‑ocular pressure, and systemic allergic reactions such as anaphylaxis. Any sudden worsening of vision or intense pain should prompt immediate medical attention.

Individuals with known hypersensitivity to pheniramine, tetryzoline, or any formulation excipients should avoid Irireact. Patients with uncontrolled glaucoma, severe ocular infections, or those advised against vasoconstrictors by their eye‑care professional should also refrain from use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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