Product image of Irsamla (Vortioxetine Hydrobromide) supplied by GNH India

Irsamla

Active Ingredient:
Vortioxetine Hydrobromide
Origin:
EU

Irsamla (Vortioxetine Hydrobromide)

Vortioxetine, the active ingredient in Irsamla, is a serotonin modulator and stimulator presented as an oral tablet for oral use. It is prescribed for the treatment of major depressive disorder in adult patients. It is indicated for patients who require a novel approach to serotonin modulation.

GNH India supplies Irsamla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Our distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Vortioxetine acts on the serotonergic system and is approved for the treatment of major depressive disorder.
  • Major depressive disorder: reduces depressive symptoms and improves overall mood in adult patients.

How It Works

  • Vortioxetine modulates multiple serotonin receptors (5‑HT1A agonist, 5‑HT1B partial agonist, 5‑HT3/5‑HT7 antagonist) while inhibiting the serotonin transporter, leading to increased extracellular serotonin and enhanced serotonergic neurotransmission throughout the central nervous system.

Side Effects

Vortioxetine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Dry mouth

Serious or Rare Side Effects

  • Serotonin syndrome
  • Suicidal thoughts or behavior
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

  • When prescribing Vortioxetine, clinicians should consider several safety precautions.
  • Monitor for worsening depression: assess suicidal ideation regularly.
  • Assess hepatic function: dose adjustment may be needed in severe liver impairment.
  • Avoid abrupt discontinuation: taper gradually to reduce withdrawal symptoms.
  • Use with caution in the elderly: increased sensitivity to side effects.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Vortioxetine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs) within 14 days
  • Other serotonergic agents (SSRIs, SNRIs, tramadol, linezolid)
  • St. John’s wort
  • Strong CYP2D6 inhibitors

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol)
  • NSAIDs (increased bleeding risk)
  • Antihypertensive agents (possible blood pressure changes)

Frequently Asked Questions

Irsamla contains vortioxetine, which is prescribed to treat major depressive disorder in adult patients. It works by enhancing serotonergic activity in the brain, helping to alleviate depressive symptoms.

Vortioxetine modulates several serotonin receptors and blocks the serotonin transporter, resulting in increased serotonin levels and improved neurotransmission across multiple pathways involved in mood regulation.

The appropriate dose of Irsamla is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to individual therapeutic needs.

The safety of vortioxetine in pregnancy and lactation has not been fully established. Clinicians should weigh potential benefits against risks and consider alternative treatments when treating pregnant or nursing individuals.

To request Irsamla, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with traditional SSRIs, vortioxetine offers a broader mechanism by targeting multiple serotonin receptors in addition to reuptake inhibition, which may result in a different side‑effect profile and potential benefits for cognitive symptoms.

Irsamla should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and keep them out of direct sunlight to maintain stability.

Irsamla is taken orally, usually once daily with or without food, as directed by the prescribing healthcare professional.

Serious risks include the potential for serotonin syndrome, emergence of suicidal thoughts or behaviors, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if these occur.

Irsamla is contraindicated in patients currently taking monoamine oxidase inhibitors, those with known hypersensitivity to vortioxetine, and individuals with a history of severe serotonin syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Vortioxetine Hydrobromide

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT