Product image of Irumed (Lisinopril) supplied by GNH India

Irumed

Active Ingredient:
Lisinopril
Origin:
EU

Irumed (Lisinopril)

Lisinopril, the active ingredient in Irumed, is an ACE inhibitor presented as an oral dosage form for oral use. It is employed to manage high blood pressure and related cardiovascular conditions in adult patients. By blocking the conversion of angiotensin I to angiotensin II, it helps relax blood vessels, lower systemic vascular resistance, and improve cardiac output.

GNH India supplies Irumed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide across multiple regions and regulatory environments.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Lisinopril is used to treat conditions related to the renin‑angiotensin system and cardiovascular disease.

  • Hypertension: lowers systemic blood pressure and reduces risk of stroke and heart attack.
  • Heart failure: improves symptoms and decreases mortality by reducing cardiac workload.
  • Post‑myocardial infarction: aids in ventricular remodeling prevention and lowers subsequent cardiovascular events.
  • Diabetic nephropathy: slows progression of kidney damage by controlling blood pressure and proteinuria.

How It Works

  • Lisinopril selectively inhibits the angiotensin‑converting enzyme (ACE), preventing the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. This inhibition also reduces aldosterone secretion, leading to decreased sodium and water retention. The resulting vasodilation and lowered blood volume lower arterial pressure, improve cardiac output, and mitigate pathological remodeling of the heart and kidneys.

Side Effects

Lisinopril may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Cough: dry, persistent cough.
  • Dizziness: especially upon standing.
  • Headache.
  • Fatigue.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or airway.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Hyperkalemia: elevated blood potassium levels that may affect heart rhythm.

Precautions & Warnings

When prescribing or dispensing lisinopril, several precautions should be observed to ensure patient safety.

  • Monitor blood pressure: check regularly to avoid hypotension.
  • Assess renal function: evaluate creatinine and eGFR before and during therapy.
  • Check serum potassium: hyperkalemia risk especially with concomitant potassium‑sparing agents.
  • Avoid use in patients with a history of angioedema: risk of recurrence.
  • Review concomitant medications: consider interactions with NSAIDs, diuretics, and other antihypertensives.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Lisinopril can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): combined use may increase risk of renal impairment, hyperkalemia, and hypotension.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalemia.
  • NSAIDs (e.g., ibuprofen): can blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors with ARBs: additive blood pressure lowering and renal risk.
  • Lithium: lisinopril may increase lithium levels, risking toxicity.
  • Thiazide diuretics: may enhance hypotensive effect, requiring dose adjustment.

Frequently Asked Questions

Irumed, which contains lisinopril, is prescribed for several cardiovascular and renal conditions. It is commonly used to treat hypertension, manage chronic heart failure, improve outcomes after a myocardial infarction, and slow the progression of diabetic nephropathy by controlling blood pressure and reducing protein loss in the urine.

Lisinopril works by inhibiting the angiotensin‑converting enzyme, which blocks the formation of angiotensin II, a powerful vasoconstrictor. With less angiotensin II, blood vessels relax and widen, peripheral resistance drops, and the kidneys excrete more sodium and water, all of which contribute to lower arterial pressure.

The appropriate dose of Irumed is determined individually by a qualified prescriber based on the patient’s medical condition, response to therapy, and any concomitant medications. Healthcare professionals will select the starting dose and any subsequent adjustments according to clinical guidelines and patient monitoring.

The safety of lisinopril during pregnancy and lactation has not been established, and ACE inhibitors are generally contraindicated in the second and third trimesters because of potential fetal toxicity. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

To order Irumed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and any necessary import documentation.

Irumed (lisinopril) is an ACE inhibitor, a class that directly blocks the conversion of angiotensin I to angiotensin II. Compared with ARBs, which block the angiotensin II receptor, ACE inhibitors also reduce bradykinin breakdown, which can lead to a characteristic cough. Efficacy in blood‑pressure control is comparable, but side‑effect profiles differ.

Irumed should be stored at room temperature, typically below 25 °C (77 °F). Keep the tablets in their original container, protect them from moisture, excessive heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink where humidity is high.

Irumed is taken orally, usually once daily, with or without food as directed by the prescribing clinician. Swallow the tablet whole with a full glass of water. Patients should follow the dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

The most serious adverse risks of Irumed include angioedema, which can involve swelling of the face, lips, tongue, or airway and requires immediate medical attention; severe hypotension, especially after the first dose or when combined with diuretics; and hyperkalemia, which can cause cardiac arrhythmias if potassium levels become excessively high.

Irumed should be avoided in individuals with a known hypersensitivity to lisinopril or any ACE inhibitor, a history of angioedema related to previous ACE‑inhibitor therapy, and in patients with severe renal impairment or those on dialysis. Caution is also advised for patients with high potassium levels or those taking potassium‑sparing agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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