Product image of Irumed (Lisinopril) supplied by GNH India

Irumed

Active Ingredient:
Lisinopril
Origin:
EU

Irumed (Lisinopril)

Lisinopril, the active ingredient in Irumed, is an ACE inhibitor presented as an oral tablet for oral use. It lowers high blood pressure and supports treatment of heart failure, post‑myocardial infarction and diabetic kidney disease in adult patients.

GNH India supplies Irumed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. With a robust distribution network, GNH India ensures timely delivery and reliable supply chain management across European and international markets.

Manufacturer / TM Owner

Belupo, S.R.O.

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Indications & Clinical Uses

  • Lisinopril is used to manage conditions within the renin‑angiotensin system that affect blood pressure and cardiac function.
  • Hypertension: reduces systolic and diastolic blood pressure, decreasing risk of stroke and cardiovascular events.
  • Heart failure: improves symptoms and lowers mortality by decreasing cardiac workload.
  • Post‑myocardial infarction: lowers the chance of subsequent heart failure and improves survival.
  • Diabetic nephropathy: slows progression of kidney damage by lowering intraglomerular pressure.

How It Works

  • Lisinopril inhibits the angiotensin‑converting enzyme (ACE), preventing the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. This results in vasodilation, reduced aldosterone secretion, decreased sodium and water retention, and ultimately lower systemic vascular resistance and blood pressure.

Side Effects

Lisinopril may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Cough: dry, persistent cough.
  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue.
  • Nausea.
  • Mild hyperkalaemia.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, potentially compromising the airway.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Acute kidney injury: sudden decline in renal function.
  • Hepatotoxicity: significant liver enzyme elevations.
  • Neutropenia or leukopenia: low white‑blood‑cell counts.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • Before prescribing Lisinopril, clinicians should evaluate several safety considerations.
  • Renal function: assess baseline creatinine and eGFR; adjust if impaired.
  • Serum potassium: monitor for hyperkalaemia, especially with potassium‑sparing diuretics.
  • Pregnancy: contraindicated in the second and third trimesters; avoid use in pregnant women.
  • Angioedema history: avoid in patients with prior ACE‑inhibitor‑induced angioedema.
  • Drug interactions: review concomitant medicines that affect potassium or renal function.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Lisinopril can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Aliskiren: combined use in diabetes increases risk of renal impairment, hyperkalaemia, and hypotension.
  • Sacubitril/valsartan: concurrent use may cause excessive angiotensin blockade and hypotension.
  • Potassium‑sparing diuretics (e.g., spironolactone): risk of severe hyperkalaemia.
  • NSAIDs (high dose): may reduce antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely)

  • Diuretics (loop or thiazide): may enhance hypotensive effect; monitor blood pressure.
  • Lithium: Lisinopril can increase lithium levels; monitor for toxicity.
  • Antidiabetic drugs (insulin, sulfonylureas): may need dose adjustment due to improved glycaemic control.
  • Rifampin: may decrease Lisinopril plasma concentration.

Frequently Asked Questions

Irumed contains lisinopril, an ACE inhibitor prescribed to lower high blood pressure, manage chronic heart failure, reduce risk after a myocardial infarction, and slow the progression of diabetic kidney disease. It works by relaxing blood vessels and decreasing fluid retention.

Lisinopril blocks the angiotensin‑converting enzyme, which prevents the formation of angiotensin II, a powerful vasoconstrictor. The resulting vasodilation, together with reduced aldosterone release, lowers systemic vascular resistance and blood pressure, easing the workload on the heart.

The appropriate dose of Irumed is determined individually by a qualified prescriber based on the patient’s medical condition, response to therapy, and any concurrent medications. Dosage adjustments may be required for renal impairment or other clinical factors.

Lisinopril is classified as Pregnancy Category D, indicating evidence of risk to the fetus, especially in the second and third trimesters. It is generally avoided during pregnancy and should be used with caution while breastfeeding, as it passes into breast milk.

To order Irumed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with beta‑blockers or calcium‑channel blockers, lisinopril directly targets the renin‑angiotensin system, offering effective blood‑pressure control and additional benefits for heart‑failure patients. It may be preferred when renal protection or reduction of proteinuria is desired, though individual response varies.

Irumed tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the label.

Irumed is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious adverse effects include angioedema (swelling of the face, lips, tongue, or throat), severe hypotension, acute kidney injury, and marked hyperkalaemia. Patients should seek immediate medical attention if they experience difficulty breathing, sudden swelling, or a drastic drop in blood pressure.

Irumed should be avoided in patients with a known hypersensitivity to lisinopril or any ACE inhibitor, a history of angioedema related to ACE‑inhibitor therapy, and in pregnant women during the second and third trimesters. Caution is also advised for individuals with severe renal impairment or high potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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