Product image of Isame (Irbesartan) supplied by GNH India

Isame

Active Ingredient:
Irbesartan
Origin:
EU

Isame (Irbesartan)

Irbesartan, the active ingredient in Isame, is an Angiotensin II receptor blocker presented as an oral tablet for oral use. It is employed to lower blood pressure and protect kidney function in patients with hypertension, diabetic nephropathy, and heart failure.

GNH India supplies Isame as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

  • Irbesartan is used to manage conditions related to the renin‑angiotensin system.
  • Hypertension: reduces systolic and diastolic blood pressure, decreasing cardiovascular risk.
  • Diabetic nephropathy: slows progression of renal impairment in patients with type 2 diabetes.
  • Heart failure: improves symptoms and reduces hospitalisation in patients with left‑ventricular dysfunction.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth‑muscle cells, adrenal glands and the kidney. By preventing angiotensin II binding, it inhibits vasoconstriction and aldosterone secretion, leading to vasodilation, reduced sodium‑water retention, and lowered blood pressure, while also providing renal protective effects.

Side Effects

Irbesartan may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Dizziness: light‑headed sensation, especially after standing.
  • Headache: mild to moderate pain in the head.
  • Fatigue: feeling unusually tired.
  • Nasal congestion: blocked or runny nose.

Serious or Rare Side Effects

  • Hyperkalemia: elevated blood potassium that can affect heart rhythm.
  • Angioedema: swelling of face, lips, tongue or throat, potentially compromising airway.
  • Renal impairment: sudden decrease in kidney function, indicated by rising creatinine.

Precautions & Warnings

When prescribing Irbesartan, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor blood pressure: check regularly to avoid hypotension.
  • Assess renal function: evaluate serum creatinine and eGFR before and during therapy.
  • Check serum potassium: avoid hyperkalemia, especially with potassium‑sparing agents.
  • Use caution in elderly: increased sensitivity to blood‑pressure lowering effects.
  • Avoid in pregnancy: drug is contraindicated due to fetal toxicity (Category D).
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Irbesartan can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics (e.g., spironolactone): risk of severe hyperkalemia.
  • ACE inhibitors or other ARBs: additive effect on blood pressure and potassium, may cause renal dysfunction.
  • Aliskiren (in diabetes): increased risk of hypotension, hyperkalemia, and renal impairment.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may reduce antihypertensive effect and impair renal function.
  • Lithium: increased lithium levels, risk of toxicity.
  • Diuretics (thiazides): may enhance potassium loss, requiring monitoring.

Frequently Asked Questions

Isame contains Irbesartan, an angiotensin II receptor blocker indicated for the treatment of hypertension, diabetic nephropathy and heart failure. It helps lower blood pressure, slows kidney damage in diabetic patients, and improves symptoms in patients with left‑ventricular dysfunction.

Irbesartan selectively blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This results in relaxed blood vessels, reduced sodium‑water retention, lower blood pressure, and protective effects on the kidneys.

The dose of Isame is individualized by the prescribing clinician based on the patient’s condition, response, and renal function. The prescriber determines the appropriate strength and titration schedule; no fixed regimen is provided here.

Irbesartan is classified as Pregnancy Category D, indicating evidence of fetal risk and it is contraindicated during pregnancy. Limited data are available for breastfeeding; the drug may pass into milk, so use is generally discouraged unless the benefit outweighs the risk.

To order Isame, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, offering similar blood‑pressure reduction to ACE inhibitors but with a lower incidence of cough and angioedema. Both classes block the renin‑angiotensin system; ARBs are often chosen when patients cannot tolerate ACE‑inhibitor‑related side effects.

Store Isame at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Isame is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels. Patients should follow the prescriber’s instructions regarding timing and any dose adjustments.

The most serious adverse events include hyperkalemia (high blood potassium), angioedema (swelling that may affect the airway), and acute renal impairment. Patients should be educated to report symptoms such as muscle weakness, facial swelling, or sudden changes in urine output promptly.

Isame should not be used by individuals with known hypersensitivity to Irbesartan or any ARB, pregnant women, patients with severe hepatic impairment, or those with a history of angioedema related to renin‑angiotensin system blockers. Clinicians should also avoid use in patients with uncontrolled hyperkalemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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