Product image of Iscover (Clopidogrel) supplied by GNH India

Iscover

Active Ingredient:
Clopidogrel
Origin:
EU

Iscover (Clopidogrel)

Clopidogrel, the active ingredient in Iscover, is an antiplatelet agent presented as an oral tablet for oral use. It helps prevent atherothrombotic events such as heart attack and stroke in patients at risk.
GNH India supplies Iscover as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Iscover (clopidogrel) acts on platelet aggregation pathways to reduce thrombotic risk.

  • Acute coronary syndrome: lowers the chance of recurrent myocardial infarction and cardiovascular death.
  • Stroke and transient ischemic attack: reduces the risk of subsequent ischemic stroke.
  • Established coronary artery disease: prevents new heart attacks and related complications.

How It Works

  • Clopidogrel is an irreversible antagonist of the platelet P2Y12 ADP receptor. By binding covalently to this receptor, it blocks ADP‑mediated activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation and thrombus formation without affecting coagulation factors.

Side Effects

Clopidogrel may cause a range of adverse reactions.

Common Side Effects

  • Minor bruising or bleeding from gums.
  • Gastrointestinal discomfort or dyspepsia.
  • Skin rash or itching.
  • Headache or dizziness.
  • Diarrhea or nausea.

Serious or Rare Side Effects

  • Severe bleeding, including intracranial hemorrhage.
  • Thrombocytopenia or neutropenia.
  • Allergic reactions such as angioedema or anaphylaxis.
  • Liver enzyme elevations.
  • Rare cases of thrombotic thrombocytopenic purpura (TTP).

Precautions & Warnings

Clopidogrel requires careful assessment before use.

  • Assess bleeding risk: evaluate history of gastrointestinal ulcers or recent surgery.
  • Monitor hematology: check platelet counts and hemoglobin regularly.
  • Adjust in renal impairment: consider dose review in severe kidney disease.
  • Caution in pregnancy: use only if benefits outweigh potential risks.
  • Avoid concomitant NSAIDs or anticoagulants unless medically indicated.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Clopidogrel interacts with several drug classes that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Proton pump inhibitors (omeprazole, esomeprazole): may reduce clopidogrel activation.
  • Strong CYP2C19 inhibitors (ticagrelor, fluconazole): can diminish antiplatelet effect.
  • Non‑steroidal anti‑inflammatory drugs (high‑dose ibuprofen, naproxen): increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): additive anticoagulation, monitor INR or bleeding signs.
  • Selective serotonin reuptake inhibitors (SSRIs): may enhance bleeding tendency.
  • Statins (simvastatin, atorvastatin): potential pharmacokinetic interaction, observe for adverse effects.

Frequently Asked Questions

Iscover contains clopidogrel, an antiplatelet medication prescribed to reduce the risk of heart attacks, strokes, and other atherothrombotic events in patients with acute coronary syndrome, established coronary artery disease, or a history of transient ischemic attack.

Clopidogrel irreversibly blocks the platelet P2Y12 ADP receptor, preventing ADP‑mediated activation of the glycoprotein IIb/IIIa complex. This inhibition stops platelets from aggregating, thereby reducing the formation of blood clots that can cause cardiovascular events.

The dosage of clopidogrel is determined by the prescribing clinician based on the patient’s medical condition, renal function, and concomitant therapies. Patients should follow the exact dosing instructions provided by their healthcare professional.

Clopidogrel is classified as pregnancy category B, indicating that animal studies have not shown risk but there are limited human data. It should be used during pregnancy or lactation only if the potential benefits justify the possible risks, and under medical supervision.

To request Iscover, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Clopidogrel differs from aspirin by selectively targeting the P2Y12 receptor rather than cyclooxygenase‑1. Compared with newer agents like ticagrelor, clopidogrel has a longer activation period and may be less potent, but it is often chosen for its established safety profile and lower cost.

Iscover tablets should be stored at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat, and direct sunlight to maintain stability and potency.

Iscover is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risks include severe or uncontrolled bleeding, such as intracranial hemorrhage, gastrointestinal bleeding, and rare blood disorders like thrombocytopenia or thrombotic thrombocytopenic purpura. Patients should seek immediate medical attention if they experience unusual bruising, blood in stool, or severe headache.

Clopidogrel is contraindicated in individuals with active pathological bleeding, known hypersensitivity to clopidogrel or any component of the formulation, and in patients with severe hepatic impairment. It should also be used with caution in those with a history of hemorrhagic stroke.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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