Product image of Isdn Retard (Isosorbide Dinitrate) supplied by GNH India

Isdn Retard

Active Ingredient:
Isosorbide Dinitrate
Origin:
EU

Isdn Retard (Isosorbide Dinitrate)

Isosorbide Dinitrate, the active ingredient in Isdn Retard, is a nitrate vasodilator presented as an oral dosage form for oral use. It is employed to treat angina pectoris and chronic heart failure by improving myocardial oxygen supply and reducing cardiac workload.

GNH India supplies Isdn Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Isdn Retard belongs to the nitrate class of anti‑anginal agents and is used in cardiovascular disease management.

  • Angina pectoris: reduces the frequency and severity of chest pain episodes by decreasing preload and afterload.
  • Chronic heart failure: alleviates symptoms and improves exercise tolerance through vasodilation and reduced cardiac filling pressures.

How It Works

  • Isosorbide dinitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of arterial and venous smooth muscle, producing vasodilation, lowering both preload and afterload, and enhancing myocardial oxygen delivery.

Side Effects

Isdn Retard may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after dosing.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warmth and redness of the skin, especially on the face.
  • Hypotension: measurable drop in blood pressure, sometimes accompanied by fatigue.

Serious or Rare Side Effects

  • Severe hypotension: can lead to syncope or shock and requires immediate medical attention.
  • Tachycardia: rapid heart rate that may be symptomatic.
  • Allergic reactions: rash, itching, or swelling of the face, lips, or tongue.
  • Methemoglobinemia: rare disorder causing reduced oxygen delivery.
  • Syncope: sudden loss of consciousness due to abrupt blood pressure fall.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Avoid abrupt discontinuation: taper the dose to prevent rebound angina.
  • Caution in anemia: reduced oxygen‑carrying capacity may worsen symptoms.
  • Concomitant PDE5 inhibitors: contraindicated because of risk of profound hypotension.
  • Drug‑induced tachycardia: monitor heart rate, especially in patients with arrhythmias.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isdn Retard can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, vardenafil (PDE5 inhibitors): may cause severe, potentially life‑threatening hypotension.
  • Other nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to dangerous blood pressure drops.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: combined effect may enhance hypotension and bradycardia.
  • Diuretics: may increase the risk of volume depletion and low blood pressure.
  • Antihypertensive agents (ACE inhibitors, ARBs, calcium channel blockers): may require dose adjustments.
  • Alcohol: can potentiate vasodilatory effects and dizziness.

Frequently Asked Questions

Isdn Retard contains isosorbide dinitrate and is prescribed to manage angina pectoris and chronic heart failure. By dilating blood vessels, it reduces cardiac workload and improves oxygen delivery to the heart muscle, helping to prevent chest pain episodes and alleviate heart‑failure symptoms.

Isosorbide dinitrate is a pro‑drug that releases nitric oxide after oral absorption. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels in vascular smooth muscle, which leads to relaxation of arteries and veins, lowering both preload and afterload and enhancing myocardial oxygen supply.

The exact dose of Isdn Retard is individualized by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage adjustments are made during therapy to achieve optimal symptom control while minimizing side effects.

Safety data for isosorbide dinitrate during pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and a healthcare professional should be consulted.

To request Isdn Retard, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Isdn Retard belongs to the nitrate class, which primarily reduces preload through venous dilation. Compared with beta‑blockers that lower heart rate and contractility, nitrates act more directly on vascular smooth muscle. Both classes are effective, but nitrates are often added when beta‑blockers alone do not control angina or when rapid symptom relief is needed.

Store Isdn Retard at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral formulation.

Isdn Retard is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing to reduce the likelihood of headache or dizziness. Swallow the tablet whole; do not crush or chew unless directed.

The most serious risks include severe hypotension, which can cause fainting or shock, and syncope. Patients should be alert for sudden drops in blood pressure, especially when standing quickly. Any signs of allergic reaction, such as rash, swelling, or difficulty breathing, require immediate medical attention.

Isdn Retard is contraindicated in patients who have taken phosphodiesterase‑5 inhibitors (e.g., sildenafil) within the past 24‑48 hours, those with severe hypotension, uncontrolled anemia, or known hypersensitivity to nitrates. Caution is also advised for patients with recent head trauma or increased intracranial pressure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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