Isicom (Levodopa, Carbidopa Monohydrate)

Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine, the neurotransmitter deficient in Parkinson's disease. Carbidopa inhibits the enzyme that converts levodopa to dopamine outside the brain, allowing more levodopa to reach the central nervous system and minimizing peripheral side effects.

The appropriate dose of Isicom is individualized by the treating physician based on disease severity, patient response, and tolerability. Dosage adjustments are made during therapy to achieve optimal symptom control while limiting adverse effects.

The safety of levodopa/carbidopa in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Isicom product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isicom combines levodopa with carbidopa, offering a higher proportion of levodopa to reach the brain compared with levodopa alone. Compared with dopamine agonists, it provides more potent symptom relief but may have a higher risk of motor complications such as dyskinesia over long‑term use.

Isicom tablets should be stored below 25 °C in a dry environment. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Isicom is taken orally, usually with a small amount of food to reduce gastrointestinal upset. Tablets are swallowed whole with water and the dosing schedule is set by the prescriber, often multiple times per day to maintain steady dopamine levels.

Serious risks include neuroleptic malignant syndrome, severe psychiatric reactions such as hallucinations or psychosis, and cardiac arrhythmias. Patients should be monitored closely for any sudden changes in mental status, temperature, muscle rigidity, or heart rhythm.

Isicom is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, or any excipients, and in individuals taking non‑selective monoamine oxidase inhibitors. Caution is also advised for patients with severe cardiovascular disease, narrow‑angle glaucoma, or a history of malignant melanoma.