Product image of Isicom Retard (Levodopa, Carbidopa Monohydrate) supplied by GNH India

Isicom Retard

Active Ingredient:
Levodopa, Carbidopa Monohydrate
Origin:
EU

Isicom Retard (Levodopa, Carbidopa Monohydrate)

Levodopa/Carbidopa, the active ingredient in Isicom Retard, is a Levodopa/Carbidopa combination presented as a standard strength tablet for oral use. It helps restore dopamine levels in the brain, thereby reducing motor symptoms of Parkinson's disease in adult patients.

GNH India supplies Isicom Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across all markets. Our distribution network adheres to stringent quality standards and provides reliable delivery to healthcare providers across Europe, Asia and the Americas.

Manufacturer / TM Owner

Desitin Arzneimittel Gmbh

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Indications & Clinical Uses

Isicom Retard, a Levodopa/Carbidopa combination, is used within the Parkinson's disease therapeutic pathway to improve motor function.

  • Parkinson's disease: alleviates bradykinesia, rigidity and tremor in patients with idiopathic Parkinson's disease.
  • Parkinsonian syndrome: improves motor symptoms caused by drug‑induced or vascular Parkinsonism.
  • Levodopa‑responsive dystonia: reduces abnormal muscle contractions in patients with dopa‑responsive dystonic disorders.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, replenishing central dopaminergic activity. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing peripheral conversion of levodopa to dopamine, thereby increasing the amount of levodopa that reaches the brain and reducing peripheral side effects.

Side Effects

Levodopa/Carbidopa therapy may be associated with a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dyskinesia: involuntary, erratic movements.
  • Dry mouth: reduced salivation.
  • Constipation: slowed bowel motility.

Serious or Rare Side Effects

  • Psychosis: hallucinations or delusional thinking.
  • Severe hypotension: marked blood pressure drop requiring medical attention.
  • Cardiac arrhythmias: irregular heart rhythms.
  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hyperpyrexia: unusually high body temperature.

Precautions & Warnings

When prescribing Isicom Retard, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic changes, especially after dose initiation.
  • Assess for dyskinesia: adjust dose if involuntary movements develop.
  • Evaluate psychiatric status: be alert for hallucinations or mood changes.
  • Adjust dose in renal impairment: consider reduced clearance in patients with kidney dysfunction.
  • Avoid abrupt discontinuation: taper gradually to prevent withdrawal symptoms.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa may interact with several other medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may diminish antiparkinsonian effect.
  • High‑dose pyridoxine (vitamin B6): can increase peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • MAO‑B inhibitors (e.g., selegiline): may potentiate dopaminergic effects.
  • Anticholinergics: may increase risk of confusion in elderly.
  • Iron supplements: can reduce levodopa absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Isicom Retard contains a levodopa/carbidopa combination and is prescribed to manage the motor symptoms of Parkinson's disease, including tremor, rigidity, and bradykinesia, in adult patients who require dopaminergic therapy.

Levodopa is a precursor that crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission. Carbidopa blocks peripheral decarboxylation of levodopa, increasing its availability to the brain and reducing peripheral side effects such as nausea.

The dosage of Isicom Retard is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s clinical condition, response, and tolerability. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for levodopa/carbidopa in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it should be prescribed under specialist supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isicom Retard provides direct dopamine replacement, whereas dopamine agonists stimulate dopamine receptors without conversion. Levodopa/carbidopa generally offers stronger symptomatic control but may be associated with motor complications over time, while agonists have a lower risk of dyskinesia but can cause sleepiness and impulse control issues.

Isicom Retard should be stored at room temperature, below 25 °C, in its original container. Keep the tablets away from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with a glass of water. It can be taken with or without food, but a consistent routine helps maintain stable plasma levels. Tablets should be swallowed whole and not crushed or chewed unless specifically instructed by a physician.

Serious adverse events include psychosis or hallucinations, severe orthostatic hypotension, cardiac arrhythmias, and rare neuroleptic malignant syndrome. Patients should be monitored for sudden changes in mental status, blood pressure drops, or any unexplained cardiac symptoms.

Isicom Retard is contraindicated in individuals with known hypersensitivity to levodopa, carbidopa, or any excipients, as well as patients with narrow‑angle glaucoma, malignant melanoma, or a history of severe cardiovascular disease where dopamine‑related effects could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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