Product image of Ismn Stada (Isosorbide Mononitrate) supplied by GNH India

Ismn Stada

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Ismn Stada (Isosorbide Mononitrate)

Isosorbide mononitrate, the active ingredient in Ismn Stada, is a organic nitrate presented as an oral tablet for oral use. It is indicated for the prevention and treatment of angina pectoris in adults with chronic stable coronary artery disease.

GNH India supplies Ismn Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Isosorbide mononitrate is used in the management of coronary artery disease‑related angina.

  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Prevention of angina pectoris: decreases episodes of chest pain during physical exertion.
  • Effort‑induced angina: provides prophylactic relief of exertional chest discomfort.

How It Works

  • Isosorbide mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of arterial and venous smooth muscle, producing vasodilation, lowering preload and afterload, and enhancing myocardial oxygen supply while reducing cardiac workload.

Side Effects

Isosorbide mononitrate may cause a range of adverse reactions.

Common Side Effects

  • Headache: often mild to moderate and transient.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation of the skin, especially on the face.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes due to inadequate cerebral perfusion.
  • Life‑threatening arrhythmias: irregular heart rhythms that may be fatal if untreated.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Dose titration: start with a low dose and increase gradually as tolerated.
  • Avoid concurrent PDE‑5 inhibitors: risk of profound hypotension.
  • Renal impairment: adjust dose or monitor renal function closely.
  • Hepatic impairment: use with caution and monitor liver function.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Isosorbide mononitrate can interact with several drug classes.

Major Interactions (Avoid)

  • Sildenafil and other PDE‑5 inhibitors: may cause severe hypotension.
  • Other organic nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to dangerous blood pressure drops.
  • Antihypertensive agents (ACE inhibitors, beta‑blockers): may enhance blood‑pressure‑lowering effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: increase risk of orthostatic hypotension.
  • Alcohol: can potentiate vasodilatory effects and dizziness.

Frequently Asked Questions

Ismn Stada contains isosorbide mononitrate and is prescribed to prevent and treat angina pectoris, particularly in patients with chronic stable coronary artery disease. It helps reduce the frequency of chest pain episodes and improves exercise tolerance.

The drug releases nitric oxide after oral absorption. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels in vascular smooth muscle, which leads to vasodilation, reduced cardiac preload and afterload, and better myocardial oxygen delivery.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isosorbide mononitrate belongs to the organic nitrate class, offering once‑daily dosing and a longer half‑life compared with short‑acting nitrates like nitroglycerin. It provides consistent prophylaxis of angina but shares similar vasodilatory side‑effects, whereas beta‑blockers work by reducing heart rate and contractility.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ismn Stada is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals to minimise gastrointestinal discomfort.

The most serious risks include severe hypotension, syncope, and life‑threatening arrhythmias. Patients should be educated to recognize signs of markedly low blood pressure, such as dizziness, fainting, or rapid heartbeat, and seek immediate medical attention if they occur.

Patients with known hypersensitivity to isosorbide mononitrate or any other organic nitrates should avoid the product. It is also contraindicated in individuals taking phosphodiesterase‑5 inhibitors for erectile dysfunction due to the risk of profound hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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