Product image of Ismn Stada (Isosorbide Mononitrate) supplied by GNH India

Ismn Stada

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Ismn Stada (Isosorbide Mononitrate)

Isosorbide mononitrate, the active ingredient in Ismn Stada, is an organic nitrate presented as an oral tablet for oral use. It is employed to prevent and treat angina pectoris in adults, helping to reduce the frequency of chest pain episodes by dilating coronary vessels and decreasing cardiac workload.

GNH India supplies Ismn Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU quality standards and is manufactured under GMP conditions and is distributed to multiple regions.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Isosorbide mononitrate is used in the anti‑anginal drug class to manage coronary artery disease‑related chest pain.
  • Prophylaxis of angina pectoris: reduces the frequency of angina attacks in patients with chronic stable angina.
  • Treatment of stable angina: improves exercise tolerance and decreases episodes of chest discomfort during physical activity.
  • Prevention of angina attacks: maintains symptom control and reduces reliance on short‑acting nitrates.

How It Works

  • After oral absorption, isosorbide mononitrate is metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous smooth muscle, producing vasodilation. This reduces both preload and afterload, decreasing myocardial oxygen demand and alleviating angina symptoms. The effect is sustained over 12‑24 hours, allowing once‑daily dosing in many regimens.

Side Effects

Isosorbide mononitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Dizziness
  • Flushing
  • Nausea

Serious or Rare Side Effects

  • Severe hypotension
  • Syncope
  • Allergic reactions such as rash or angioedema
  • Stevens‑Johnson syndrome (rare)

Precautions & Warnings

  • Careful monitoring and patient education are essential when using isosorbide mononitrate.
  • Monitor blood pressure: check for hypotension especially after dose initiation or dose changes.
  • Avoid abrupt discontinuation: taper to prevent rebound angina.
  • Use caution in hepatic impairment: metabolism may be reduced.
  • Assess for nitrate tolerance: effectiveness may diminish with continuous use.
  • Avoid concomitant use with phosphodiesterase‑5 inhibitors: risk of profound hypotension.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Isosorbide mononitrate can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): may cause severe hypotension.
  • Other nitrates or nitroglycerin preparations: additive vasodilatory effect leading to dangerous blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (ACE inhibitors, beta‑blockers, calcium channel blockers): may enhance blood pressure‑lowering effect.
  • Alcohol consumption: can increase hypotensive response.
  • Diuretics: may potentiate volume depletion and orthostatic symptoms.

Frequently Asked Questions

Ismn Stada contains isosorbide mononitrate, which is prescribed to prevent episodes of angina pectoris and to treat stable angina. It helps reduce the frequency and severity of chest pain by improving blood flow to the heart muscle.

After oral intake, isosorbide mononitrate is converted to nitric oxide. The nitric oxide activates guanylate cyclase, raising cyclic GMP levels in vascular smooth muscle. This causes relaxation of arteries and veins, lowering both preload and afterload, which decreases the heart’s oxygen demand and relieves angina.

The specific dose of Ismn Stada is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage may be adjusted over time, and any changes should be made under medical supervision.

Safety data for isosorbide mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ismn Stada, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isosorbide mononitrate belongs to the organic nitrate class, offering longer‑acting vasodilation compared with short‑acting nitroglycerin. Unlike beta‑blockers, it primarily reduces cardiac preload and afterload rather than heart rate. Its once‑daily dosing can improve adherence, but tolerance may develop with continuous use, requiring drug‑free intervals.

Store Ismn Stada at room temperature, below 25 °C, in the original packaging. Keep the tablets away from moisture, direct sunlight and heat sources. Do not store in the bathroom or near a kitchen sink where humidity is high.

Ismn Stada is taken orally as a tablet. Swallow the tablet whole with a glass of water; it should not be crushed, chewed, or broken unless specifically instructed by a healthcare professional.

The most serious risks include severe hypotension, syncope, and allergic reactions such as rash, angioedema, or rare severe skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic reaction.

Ismn Stada should be avoided in patients who are currently taking other nitrate preparations, phosphodiesterase‑5 inhibitors, or who have severe hypotension. It is also contraindicated in individuals with known hypersensitivity to isosorbide mononitrate or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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