Product image of Ismn Stada (Isosorbide 5 Mononitrate) supplied by GNH India

Ismn Stada

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Ismn Stada (Isosorbide 5 Mononitrate)

Isosorbide-5-Mononitrate, the active ingredient in Ismn, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to manage chronic stable angina by improving myocardial oxygen balance in adult patients. The drug releases nitric oxide, causing peripheral venous dilation, which reduces cardiac preload and afterload, thereby decreasing myocardial oxygen demand.

GNH India supplies Ismn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across all markets.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Ismn, a nitrate vasodilator, is used in the management of coronary artery disease‑related angina.

  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Effort‑induced angina: decreases chest pain during physical activity.
  • Ischemic heart disease: helps alleviate myocardial ischemia‑related discomfort.

How It Works

  • Isosorbide‑5‑mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous smooth muscle, producing vasodilation. This reduces both preload and afterload, lowers myocardial oxygen consumption, and improves the balance between oxygen supply and demand in the heart. The effect is sustained over 12‑24 hours, allowing once‑daily dosing in many regimens.

Side Effects

Ismn may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache
  • Dizziness
  • Flushing
  • Hypotension
  • Nausea
  • Palpitations

Serious or Rare Side Effects

  • Severe hypotension
  • Syncope
  • Myocardial infarction
  • Life‑threatening arrhythmias
  • Methemoglobinemia
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

When prescribing Ismn, clinicians should consider specific safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rate before initiating therapy.
  • Concomitant nitrate use: avoid combining with other nitrate preparations to prevent excessive hypotension.
  • Phosphodiesterase‑5 inhibitors: do not use with sildenafil, tadalafil, or vardenafil due to risk of severe hypotension.
  • Hepatic or renal impairment: adjust therapy cautiously and monitor for accumulation.
  • Pregnancy and lactation: use only if clearly needed; safety data are limited.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Ismn can interact with several drug classes; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Other nitrate preparations (e.g., nitroglycerin) – risk of profound hypotension.
  • Phosphodiesterase‑5 inhibitors (sildenafil, tadalafil, vardenafil) – may cause severe blood pressure drops.
  • Potent antihypertensives (e.g., intravenous nitroprusside) – additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Diuretics – may enhance blood pressure‑lowering effect.
  • Beta‑blockers – combined effect on heart rate and blood pressure.
  • Calcium channel blockers – possible additive vasodilation.
  • Antiplatelet agents – monitor for increased bleeding risk.
  • CYP3A4 inhibitors – may increase plasma levels of isosorbide‑5‑mononitrate.

Frequently Asked Questions

Ismn contains isosorbide‑5‑mononitrate, a nitrate vasodilator indicated for the treatment of chronic stable angina. It helps reduce the frequency of chest pain episodes and improves exercise tolerance in patients with coronary artery disease.

The molecule donates nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of arteries and veins, lowering preload and afterload, and ultimately decreasing the heart’s oxygen demand.

The appropriate dose of Ismn is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage regimens are individualized and should follow local prescribing guidelines.

Safety data for isosorbide‑5‑mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Ismn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ismn belongs to the nitrate class, offering rapid onset of vasodilation and a longer half‑life than short‑acting nitrates like nitroglycerin. Compared with beta‑blockers or calcium‑channel blockers, nitrates primarily reduce preload, making them useful as adjunct therapy or when other agents are contraindicated.

Store Ismn tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and light, and ensure the container is tightly closed to maintain stability.

Ismn is taken orally, usually as a tablet swallowed whole with water. It is generally administered once daily, but the exact schedule should follow the prescribing clinician’s instructions.

Serious adverse events include severe hypotension, syncope, myocardial infarction, life‑threatening arrhythmias, methemoglobinemia, and anaphylactic reactions. Patients should be monitored for sudden drops in blood pressure, especially when combined with other vasodilators.

Ismn is contraindicated in patients with known hypersensitivity to isosorbide‑5‑mononitrate or any nitrate, those who have taken phosphodiesterase‑5 inhibitors within 24‑48 hours, and patients with severe hypotension or uncontrolled shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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