Product image of Ismo 10 (Isosorbide 5 Mononitrate) supplied by GNH India

Ismo 10

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Ismo 10 (Isosorbide 5 Mononitrate)

Isosorbide 5-Mononitrate, the active ingredient in Ismo 10, is a nitrate vasodilator presented as an oral tablet for oral use. It is used to prevent and treat chronic stable angina in adult patients.

GNH India supplies Ismo 10 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Esteve Pharmaceuticals Gmbh

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Indications & Clinical Uses

Isosorbide 5-Mononitrate acts on the coronary circulation to relieve angina and is indicated for the following conditions:

  • Prophylaxis of angina pectoris: reduces the frequency and severity of angina attacks.
  • Treatment of chronic stable angina: improves exercise tolerance and decreases myocardial oxygen demand.
  • Angina pectoris (symptomatic relief): provides rapid vasodilation to alleviate chest pain during episodes.

How It Works

  • Isosorbide 5-Mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of both veins and arteries, lowering preload and afterload, decreasing myocardial oxygen consumption, and thereby alleviating angina symptoms.

Side Effects

Isosorbide 5-Mononitrate may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Headache: often transient and related to vasodilation.
  • Dizziness or light‑headedness: especially on standing.
  • Flushing: warm sensation of the skin.
  • Hypotension: mild to moderate drop in blood pressure.
  • Nausea or abdominal discomfort.
  • Tachycardia: compensatory increase in heart rate.

Serious or Rare Side Effects

  • Severe hypotension leading to syncope.
  • Myocardial infarction in susceptible individuals.
  • Allergic reactions such as rash or angioedema.
  • Methemoglobinemia: rare but potentially life‑threatening.
  • Persistent headache unresponsive to therapy.
  • Cardiac arrhythmias.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rate baseline.
  • Concomitant nitrates: avoid combined use to prevent excessive vasodilation.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of severe hypotension.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Renal or hepatic impairment: monitor for accumulation and adjust therapy if needed.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Isosorbide 5-Mononitrate interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound hypotension.
  • Other nitrates (e.g., nitroglycerin): additive vasodilatory effect.
  • Strong antihypertensives: may cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance hypotensive effect.
  • Diuretics: may increase orthostatic blood pressure drop.
  • Beta‑blockers: monitor heart rate and angina control.
  • Calcium‑channel blockers: watch for synergistic blood pressure lowering.

Frequently Asked Questions

Ismo 10 contains isosorbide 5‑mononitrate, a nitrate vasodilator prescribed to prevent and treat chronic stable angina. It helps reduce the frequency of chest pain episodes by lowering the heart's oxygen demand.

The drug releases nitric oxide in the bloodstream, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing veins and arteries to relax, decreasing preload and afterload, and ultimately reducing myocardial oxygen consumption.

The dosage of Ismo 10 is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerance. Physicians determine the appropriate strength and frequency according to established guidelines.

Safety data for isosorbide 5‑mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To request Ismo 10, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ismo 10 belongs to the nitrate class, offering rapid vasodilation and ease of oral administration. Compared with beta‑blockers or calcium‑channel blockers, nitrates primarily reduce preload, making them especially useful for patients who need quick relief of angina symptoms or who cannot tolerate other classes.

Ismo 10 should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve tablet integrity and potency throughout its shelf life.

Ismo 10 is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless the prescriber provides specific instructions for a different administration method.

Serious risks include severe hypotension, syncope, myocardial infarction, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, chest pain, or signs of an allergic response.

Ismo 10 is contraindicated in patients who have taken phosphodiesterase‑5 inhibitors within the past 24 hours, those with known hypersensitivity to isosorbide nitrates, or individuals with severe hypotension. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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