Ismo (Isosorbide 5 Mononitrate)

The molecule releases nitric oxide in the bloodstream, which activates soluble guanylate cyclase. This raises cyclic GMP levels, causing smooth‑muscle relaxation in arteries and veins, leading to vasodilation, lower cardiac preload and afterload, and reduced myocardial oxygen consumption.

The appropriate dose of Ismo is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage may be adjusted over time, and patients should follow the exact regimen provided by their healthcare professional.

Safety data for isosorbide 5‑mononitrate in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their physician.

To request Ismo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ismo belongs to the organic nitrate class, offering longer‑acting vasodilation compared with short‑acting nitroglycerin. Unlike beta‑blockers, it primarily reduces preload rather than heart rate. Its once‑daily dosing can improve adherence, but tolerance may develop, requiring periodic drug‑free intervals.

Store Ismo at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ismo is taken orally as a tablet. Swallow the tablet whole with a glass of water; it may be taken with or without food. Patients should follow the dosing schedule prescribed by their clinician and avoid crushing or chewing the tablet.

The most serious adverse events include severe hypotension, syncope, myocardial infarction, and rare allergic reactions such as rash or angioedema. Prompt medical attention is required if any of these symptoms occur, especially sudden drops in blood pressure or chest pain.

Ismo should be avoided in patients with severe hypotension, recent use of phosphodiesterase‑5 inhibitors (e.g., sildenafil), known hypersensitivity to organic nitrates, or those with a history of severe anemia or methemoglobinemia. Clinicians must evaluate each patient’s medical history before prescribing.