Product image of Ismo (Isosorbide 5 Mononitrate) supplied by GNH India

Ismo

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Ismo (Isosorbide 5 Mononitrate)

Isosorbide 5-mononitrate, the active ingredient in Ismo, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to prevent and treat episodes of angina pectoris in adults with coronary artery disease by reducing myocardial oxygen demand.

GNH India supplies Ismo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, reliable delivery, and comprehensive support for regulatory and procurement documentation.

Manufacturer / TM Owner

Esteve Pharmaceuticals Gmbh

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Indications & Clinical Uses

  • Ismo, a nitrate vasodilator, is used in the management of angina‑related conditions.
  • Stable angina pectoris: reduces frequency and severity of chest‑pain episodes.
  • Chronic stable angina: improves exercise tolerance and delays onset of pain.
  • Exercise‑induced angina: prevents pain during physical exertion.

How It Works

  • Isosorbide 5‑mononitrate releases nitric oxide in vascular smooth muscle, activating guanylate cyclase and increasing cyclic GMP levels. Elevated cGMP causes relaxation of veins and arteries, lowering preload and afterload, which reduces myocardial oxygen consumption and alleviates anginal symptoms.

Side Effects

Ismo may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Headache: often transient and dose‑related.
  • Flushing: warm sensation, usually mild.
  • Dizziness or light‑headedness.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes due to low blood pressure.
  • Allergic reactions: rash, angioedema, or anaphylaxis in rare cases.

Precautions & Warnings

  • When prescribing Ismo, clinicians should consider several safety measures.
  • Avoid abrupt discontinuation: may precipitate recurrence of angina.
  • Monitor blood pressure: risk of hypotension, especially in volume‑depleted patients.
  • Use with caution in hepatic impairment: altered drug metabolism may increase exposure.
  • Avoid concurrent use with phosphodiesterase‑5 inhibitors: risk of profound hypotension.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Ismo can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, and other PDE‑5 inhibitors: may cause severe hypotension.
  • Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect leading to dangerous blood‑pressure drops.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors, ARBs): may enhance blood‑pressure‑lowering effect.
  • Alcohol: can increase vasodilatory response and dizziness.
  • Diuretics: may potentiate hypotensive effect, requiring blood‑pressure monitoring.

Frequently Asked Questions

Ismo contains isosorbide 5‑mononitrate, a nitrate vasodilator indicated for the prophylaxis and treatment of angina pectoris in patients with coronary artery disease. It helps reduce the frequency and severity of chest‑pain episodes.

Isosorbide 5‑mononitrate donates nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of veins and arteries, lowering preload and afterload, and consequently decreasing myocardial oxygen demand.

The dosage regimen is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. The prescriber determines the appropriate strength and frequency for each patient.

Safety data are limited and the product is classified as pregnancy category unknown. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and under close medical supervision.

Submit an enquiry on the Ismo product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with short‑acting nitrates, isosorbide 5‑mononitrate offers a longer duration of action and typically once‑daily dosing, providing more stable plasma levels. Unlike beta‑blockers or calcium‑channel blockers, it works via nitric‑oxide mediated vasodilation and can be combined with those classes for additive effect.

Store at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date.

Ismo is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risks include severe hypotension, syncope, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic response.

Ismo is contraindicated in patients with known hypersensitivity to isosorbide 5‑mononitrate or other organic nitrates, and in those who have taken phosphodiesterase‑5 inhibitors within the past 24 hours due to the risk of profound hypotension. Caution is also advised in severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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