Ismo (Isosorbide Mononitrate)

Isosorbide mononitrate is converted in the body to nitric oxide, a potent vasodilator. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels, which relaxes smooth muscle in veins and arteries. This lowers cardiac preload and afterload, improving oxygen delivery to the myocardium while decreasing the heart's workload.

The dosage of Ismo is individualized by a qualified healthcare professional based on the patient’s clinical condition, response, and tolerability. Prescribers determine the appropriate strength, frequency, and any titration schedule, and patients should follow the exact instructions provided on the prescription label.

Safety data for isosorbide mononitrate in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Ismo.

To request Ismo, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs), and required import documentation.

Ismo belongs to the nitrate class, offering a longer‑acting oral option compared with short‑acting nitroglycerin tablets or sprays. Unlike beta‑blockers, it primarily reduces cardiac preload rather than heart rate, making it useful when heart rate control is not desired. Its once‑daily dosing can improve adherence relative to multiple‑dose regimens of other nitrates.

Ismo should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Ismo is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber. Swallow the tablet whole; do not crush, chew, or split it unless directed by a healthcare professional.

The most serious risks include severe hypotension, syncope (fainting), and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, rapid heartbeat, swelling of the face or throat, or any signs of an allergic response.

Ismo is contraindicated in patients with severe hypotension, recent myocardial infarction, uncontrolled heart failure, or those currently using other nitrate preparations or phosphodiesterase‑5 inhibitors. Individuals with known hypersensitivity to isosorbide mononitrate or any component of the formulation should also avoid using the product.