Ismo Retard (Isosorbide 5 Mononitrate)

The active ingredient releases nitric oxide in the bloodstream, which activates guanylate cyclase in vascular smooth‑muscle cells. This raises cGMP levels, causing the muscles to relax, dilating arteries and veins, lowering cardiac preload and afterload, and improving oxygen delivery to the myocardium.

The dosage of Ismo Retard is determined individually by the prescribing clinician based on the patient’s clinical condition, response, and tolerance. Patients should follow the exact regimen provided by their healthcare professional and not adjust the dose on their own.

Safety data for Isosorbide 5‑Mononitrate in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Ismo Retard product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ismo Retard belongs to the nitrate class, which provides rapid vasodilation and is particularly effective for prophylaxis of angina. Compared with beta‑blockers or calcium‑channel blockers, nitrates have a distinct mechanism and are often used in combination when monotherapy does not achieve adequate symptom control.

Ismo Retard should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Ismo Retard is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional.

The most serious adverse events include severe hypotension, syncope, myocardial infarction, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, chest pain worsening, or signs of an allergic response.

Ismo Retard is contraindicated in patients who are currently taking other nitrate medications, have severe hypotension, or have known hypersensitivity to Isosorbide 5‑Mononitrate or any excipients. It should also be avoided in individuals using phosphodiesterase‑5 inhibitors without medical supervision.