Product image of Ismox Depot (Isosorbide 5 Mononitrate) supplied by GNH India

Ismox Depot

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Ismox Depot (Isosorbide 5 Mononitrate)

Isosorbide 5 Mononitrate, the active ingredient in Ismox Depot, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed in the prophylaxis and treatment of angina pectoris, helping to reduce the frequency of chest pain episodes in patients with chronic stable angina.

GNH India supplies Ismox Depot as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Esteve Pharmaceuticals Gmbh

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Indications & Clinical Uses

Ismox Depot, a nitrate vasodilator, is indicated for conditions involving myocardial ischemia and angina.

  • Prophylaxis of angina pectoris: reduces the frequency of angina attacks during daily activities.
  • Treatment of chronic stable angina: improves exercise tolerance and decreases symptom burden.
  • Management of coronary artery disease: alleviates myocardial oxygen demand by lowering preload and afterload.

How It Works

  • Isosorbide 5 Mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous vessels, decreasing preload and afterload, and thereby improving myocardial oxygen supply while reducing cardiac workload.

Side Effects

Ismox Depot may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Dizziness or light‑headedness: related to blood pressure lowering.
  • Flushing: warm sensation, especially after the first dose.
  • Nausea: occasional gastrointestinal upset.
  • Palpitations: awareness of heartbeat changes.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes due to inadequate cerebral perfusion.
  • Allergic reactions: rash, itching, or swelling that may progress to anaphylaxis.
  • Methemoglobinemia: rare blood disorder causing reduced oxygen delivery.
  • Myocardial infarction: extremely rare but reported in susceptible individuals.

Precautions & Warnings

Before initiating therapy with Ismox Depot, consider the following safety measures.

  • Discontinue use gradually: avoid abrupt cessation to prevent rebound angina.
  • Monitor blood pressure: watch for symptomatic hypotension, especially after the first dose.
  • Hepatic impairment: use cautiously, as metabolism may be altered.
  • Concomitant PDE‑5 inhibitors: avoid combined use due to risk of severe hypotension.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare professional.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ismox Depot can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other nitrates (e.g., isosorbide dinitrate): additive vasodilatory effect leading to profound hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe blood pressure fall.
  • Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance hypotensive response.
  • Diuretics: may increase dehydration and lower blood pressure.
  • Beta‑blockers: additive effect on heart rate and blood pressure, requiring dose adjustments.

Frequently Asked Questions

Ismox Depot contains isosorbide 5 mononitrate, a nitrate vasodilator indicated for the prophylaxis and treatment of angina pectoris. It helps reduce the frequency of chest pain episodes in patients with chronic stable angina by improving myocardial oxygen supply.

The compound donates nitric oxide after oral absorption. Nitric oxide activates guanylate cyclase in vascular smooth muscle, raising cyclic GMP levels, which relaxes arteries and veins. This vasodilation lowers cardiac preload and afterload, decreasing myocardial oxygen demand and relieving angina.

The appropriate dose of Ismox Depot is determined by the prescribing healthcare professional based on the individual’s clinical condition, response, and tolerance. Patients should follow the specific dosing instructions provided by their physician and not adjust the dose on their own.

Safety data for isosorbide 5 mononitrate in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using this medication.

To request Ismox Depot, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ismox Depot belongs to the nitrate class, offering rapid onset of vasodilation and convenient once‑daily dosing. Compared with other antianginals such as beta‑blockers or calcium‑channel blockers, nitrates primarily reduce preload, whereas the alternatives affect heart rate or contractility. Choice of therapy depends on patient comorbidities, tolerance, and physician preference.

Store Ismox Depot at room temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Ismox Depot is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow their prescriber’s instructions regarding timing, especially when initiating therapy, to minimize the risk of dizziness or headache.

The most serious adverse events include severe hypotension, syncope (fainting), and rare allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, chest pain, or signs of an allergic response.

Ismox Depot is contraindicated in patients with known hypersensitivity to isosorbide mononitrate or any other nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24 hours, and individuals with severe anemia or closed‑angle glaucoma. Clinicians should also exercise caution in patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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