Product image of Isochol (Hymecromone) supplied by GNH India

Isochol

Active Ingredient:
Hymecromone
Origin:
EU

Isochol (Hymecromone)

Hymecromone, the active ingredient in Isochol, is a choleretic presented as an oral dosage form for oral use. It is employed to stimulate bile secretion and flow in patients with biliary disorders, cholestasis, and gallstone disease.
GNH India supplies Isochol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Isochol acts as a choleretic agent addressing disorders of bile production and flow.

  • Biliary disorders: enhances bile output to improve digestion and relieve cholestatic symptoms.
  • Cholestasis: promotes bile flow, helping to reduce intra‑hepatic bile accumulation.
  • Gallstone disease: facilitates bile movement, supporting the prevention of stone formation and aiding in symptom management.

How It Works

  • Hymecromone increases bile secretion by stimulating hepatocellular production of bile acids and enhancing the activity of the bile salt export pump. It also inhibits hyaluronan synthesis, which may contribute to reduced bile viscosity and improved biliary drainage, thereby supporting normal hepatic excretory function.

Side Effects

Adverse reactions may occur with any medication and should be monitored.

Common Side Effects

  • Diarrhea: loose stools occurring during treatment.
  • Abdominal discomfort: mild pain or cramping in the upper abdomen.
  • Nausea: feeling of queasiness without vomiting.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Hepatic enzyme elevation: significant rise in liver function tests.
  • Allergic reaction: rash, itching, or swelling of the face and throat.
  • Severe abdominal pain: persistent or worsening pain requiring medical evaluation.

Precautions & Warnings

Before initiating Isochol, consider the following safety measures.

  • Liver function monitoring: assess baseline enzymes and repeat as clinically indicated.
  • Pregnancy and lactation: use only if the potential benefit outweighs potential risk.
  • Concomitant liver disease: evaluate severity and adjust therapy accordingly.
  • Drug interactions: review patient medication list for potential interactions.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Isochol may interact with other agents that affect bile metabolism or hepatic function.

Major Interactions (Avoid)

  • Cyclosporine: may increase risk of hepatotoxicity.
  • Rifampicin: can reduce Hymecromone effectiveness by inducing hepatic enzymes.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible alteration of bile composition.
  • Statins: monitor liver enzymes for additive hepatic stress.
  • Antifungal azoles: may affect hepatic metabolism pathways.

Frequently Asked Questions

Isochol, containing Hymecromone, is used to manage biliary disorders, cholestasis, and gallstone disease by stimulating bile production and flow, which helps alleviate symptoms associated with impaired bile secretion.

Hymecromone enhances bile secretion by increasing hepatocellular synthesis of bile acids and activating transport mechanisms that move bile into the gastrointestinal tract. It also reduces hyaluronan synthesis, which can lower bile viscosity and improve drainage.

The dosage of Isochol is determined by the prescribing healthcare professional based on the patient’s specific condition, severity, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Hymecromone in pregnancy and lactation are limited. Isochol should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Isochol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Isochol’s active ingredient, Hymecromone, uniquely combines bile‑stimulating activity with inhibition of hyaluronan synthesis, which may offer advantages in reducing bile viscosity compared with some other choleretics that solely increase bile acid secretion.

Isochol should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Isochol is taken orally, usually with a glass of water. The exact timing relative to meals should follow the prescribing clinician’s guidance, as food may influence absorption for some patients.

Serious risks include significant elevation of liver enzymes indicating hepatic injury, severe allergic reactions such as rash or swelling, and persistent abdominal pain. Patients experiencing these symptoms should seek immediate medical attention.

Isochol is contraindicated in patients with known hypersensitivity to Hymecromone or any excipients in the formulation, and it should be used with caution in individuals with severe liver impairment or active hepatic disease unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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