Product image of Isocolan (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 4) supplied by GNH India

Isocolan

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 4
Origin:
EU

Isocolan (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Sodium Sulfate Anhydrous, Macrogol 4)

Sodium Hydrogen Carbonate, the active ingredient in Isocolan, is an electrolyte replenishment agent presented as an oral solution for oral use. It is combined with potassium chloride, sodium chloride, sodium sulfate anhydrous and macrogol 4 to help restore fluid and electrolyte balance in patients who have experienced fluid loss.
GNH India supplies Isocolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polifarma S.P.A

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Indications & Clinical Uses

Isocolan is used primarily to address conditions that involve fluid and electrolyte disturbances.

  • Dehydration: helps re‑hydrate patients by providing sodium, potassium and chloride ions.
  • Electrolyte imbalance: restores normal plasma electrolyte concentrations after losses due to diarrhea or vomiting.
  • Bowel preparation: macrogol 4 acts as an osmotic laxative to cleanse the colon before diagnostic procedures.

How It Works

  • Isocolan works by delivering a balanced mixture of sodium, potassium, chloride and sulfate ions that are readily absorbed in the gastrointestinal tract, thereby correcting extracellular fluid deficits. The macrogol 4 component retains water in the intestinal lumen, creating an osmotic gradient that promotes gentle bowel cleansing and facilitates electrolyte absorption.

Side Effects

Common Side Effects

  • Mild abdominal discomfort: transient stomach cramping.
  • Nausea: occasional feeling of queasiness.
  • Diarrhea: loose stools due to osmotic activity.
  • Flatulence: increased intestinal gas.
  • Taste alteration: temporary change in mouthfeel.

Serious or Rare Side Effects

  • Severe electrolyte disturbance: hypernatremia or hyperkalemia.
  • Allergic reaction: rash, itching, swelling.
  • Persistent vomiting: may lead to further fluid loss.
  • Acute renal impairment: in patients with pre‑existing kidney disease.

Precautions & Warnings

Before using Isocolan, consider the following precautions:

  • Renal function: assess kidney status in patients with chronic kidney disease.
  • Cardiac conditions: monitor electrolyte levels in patients with heart failure.
  • Fluid status: avoid in patients with fluid overload or edema.
  • Pregnancy and lactation: use only if clearly needed and prescribed.
  • Drug interactions: review concomitant medications that affect electrolyte balance.
  • Store at ambient temperature: keep below 25°C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Isocolan may interact with other agents that influence electrolyte balance.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • Sodium‑containing IV fluids: may cause hypernatremia.
  • ACE inhibitors or ARBs: can exacerbate potassium elevation.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may require electrolyte monitoring.
  • Laxatives other than macrogol: increase risk of dehydration.
  • Antacids containing sodium: additive sodium load.
  • Certain antibiotics (e.g., aminoglycosides): monitor renal function and electrolytes.

Frequently Asked Questions

Isocolan is an oral electrolyte solution designed to re‑hydrate patients and correct electrolyte disturbances caused by fluid loss, such as dehydration, electrolyte imbalance, and to aid bowel preparation before certain medical procedures.

Sodium Hydrogen Carbonate provides bicarbonate ions that help buffer acidity, while the accompanying salts supply sodium, potassium and chloride. Together they restore extracellular fluid volume and electrolyte concentrations, and macrogol 4 creates an osmotic effect that draws water into the intestines.

The dose of Isocolan is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and the extent of fluid loss. Dosage instructions are provided on the prescription label.

Isocolan should be used during pregnancy or lactation only if clearly needed and prescribed by a qualified clinician. The benefits must outweigh any potential risks to the mother or infant, and electrolyte monitoring may be advisable.

To order Isocolan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isocolan combines multiple electrolytes with macrogol 4, offering both rehydration and mild bowel cleansing. Compared with standard oral rehydration salts, it provides a broader electrolyte profile and an osmotic laxative effect, which may be advantageous in settings requiring both fluid replacement and colon preparation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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