Product image of Isofluran Baxter (Isoflurane) supplied by GNH India

Isofluran Baxter

Active Ingredient:
Isoflurane
Origin:
EU

Isofluran Baxter (Isoflurane)

Isoflurane, the active ingredient in Isofluran Baxter, is a volatile anesthetic presented as a liquid for inhalation use. It produces rapid loss of consciousness and analgesia, making it suitable for induction and maintenance of general anesthesia in adult and pediatric surgical patients.

GNH India supplies Isofluran Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics and responsive technical support.

Manufacturer / TM Owner

Baxter Oy

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Indications & Clinical Uses

Isoflurane is a volatile anesthetic used in the central nervous system to produce reversible loss of consciousness.

  • Induction of general anesthesia: rapid onset of unconsciousness for surgical procedures
  • Maintenance of general anesthesia: sustained anesthetic depth throughout operations
  • Procedural sedation: provides deep sedation for short diagnostic or therapeutic procedures

How It Works

  • Isoflurane acts by potentiating the inhibitory GABA_A receptor and simultaneously inhibiting excitatory NMDA receptors in the central nervous system. This dual action enhances neuronal chloride influx and reduces excitatory glutamate signaling, leading to decreased neuronal firing, loss of consciousness, and analgesia required for surgical anesthesia.

Side Effects

Isoflurane may cause a range of adverse reactions during and after administration.

Common Side Effects

  • Airway irritation: cough or laryngospasm
  • Hypotension: decreased blood pressure
  • Respiratory depression: reduced ventilation
  • Nausea: mild postoperative nausea

Serious or Rare Side Effects

  • Malignant hyperthermia: rare life‑threatening hypermetabolic reaction
  • Hepatotoxicity: rare elevation of liver enzymes
  • Cardiac arrhythmia: occasional abnormal heart rhythms

Precautions & Warnings

Isoflurane requires careful patient assessment and monitoring before and during use.

  • Patient monitoring: continuous cardiovascular and respiratory monitoring required
  • Pre‑existing liver disease: use with caution
  • Pregnancy: safety not established, avoid if possible
  • Concurrent CNS depressants: may potentiate respiratory depression
  • Malignant hyperthermia susceptibility: contraindicated
  • Store at ambient temperature: keep container sealed, protect from light and moisture

Avoid Interactions

Isoflurane can interact with other agents, altering its anesthetic profile.

Major Interactions (Avoid)

  • Potent CYP2E1 inhibitors: may increase isoflurane concentrations
  • Halothane or other volatile anesthetics: additive CNS depression
  • Neuromuscular blocking agents: may potentiate blockade

Moderate Interactions (Monitor Closely)

  • Inhaled nitrous oxide: may affect minimum alveolar concentration (MAC)
  • Beta‑blockers: may enhance hypotensive effect
  • Diuretics: may exacerbate renal hypoperfusion

Frequently Asked Questions

Isofluran Baxter contains isoflurane, a volatile anesthetic that is used to induce and maintain general anesthesia in patients undergoing surgical or diagnostic procedures. It provides rapid loss of consciousness and analgesia, allowing safe performance of operations.

Isoflurane works by enhancing the activity of GABA_A receptors, which increases inhibitory neurotransmission, and by blocking NMDA receptors, reducing excitatory signaling. This combined effect depresses neuronal activity, leading to unconsciousness and analgesia required for anesthesia.

The specific dose and concentration of Isofluran Baxter are determined by the treating anesthesiologist based on the patient’s age, weight, health status, and the type of procedure. The prescriber sets the appropriate vaporizer settings and administration parameters.

The safety of isoflurane during pregnancy and lactation has not been established. It is generally avoided in pregnant patients unless the benefits outweigh the potential risks, and breastfeeding mothers should consult their healthcare provider before exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Isoflurane offers a relatively low blood‑gas partition coefficient, providing faster induction and recovery compared with agents like halothane, while maintaining stable cardiovascular profiles. It is often chosen for its predictable depth of anesthesia and lower incidence of hepatic toxicity relative to older volatile agents.

Isofluran Baxter should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from direct sunlight, moisture, and physical damage. Ensure the vaporizer and delivery system are cleaned according to manufacturer guidelines before use.

Isofluran Baxter is administered via inhalation using a calibrated vaporizer attached to a breathing circuit. The anesthesiologist adjusts the vaporizer setting to achieve the desired minimum alveolar concentration (MAC) while continuously monitoring the patient’s vital signs.

The most serious risks include malignant hyperthermia, a rare but life‑threatening hypermetabolic reaction, severe hypotension, and respiratory depression. Prompt recognition and treatment are essential, and patients with known susceptibility to malignant hyperthermia should not receive isoflurane.

Isofluran Baxter should be avoided in patients with a known susceptibility to malignant hyperthermia, severe hepatic impairment, or uncontrolled cardiovascular instability. It is also contraindicated in pregnant women unless absolutely necessary and should be used with caution in patients taking other central nervous system depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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