Product image of Isofluran Baxter (Isoflurane) supplied by GNH India

Isofluran Baxter

Active Ingredient:
Isoflurane
Origin:
EU

Isofluran Baxter (Isoflurane)

Isoflurane, the active ingredient in Isofluran Baxter, is an inhalational anesthetic presented as a solution for inhalation use. It is used to induce and maintain general anesthesia in surgical patients.

GNH India supplies Isofluran Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Baxter Medical Ab

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Indications & Clinical Uses

Isoflurane is an inhalational anesthetic used in the management of the central nervous system to achieve controlled loss of consciousness during surgery.

  • Induction of general anesthesia: provides rapid onset of unconsciousness for surgical procedures.
  • Maintenance of general anesthesia: sustains adequate depth of anesthesia throughout operations.
  • Pediatric anesthesia: enables safe and controlled anesthesia in children undergoing surgery.

How It Works

  • Isoflurane acts by potentiating the activity of the GABA_A receptor, enhancing inhibitory neurotransmission and reducing neuronal excitability. This leads to a dose‑dependent depression of the central nervous system, producing loss of consciousness, analgesia, and muscle relaxation required for surgical anesthesia.

Side Effects

Isoflurane may cause a range of adverse reactions during and after administration.

Common Side Effects

  • Cough or airway irritation
  • Nausea and vomiting
  • Hypotension
  • Tachycardia
  • Dizziness
  • Dry mouth

Serious or Rare Side Effects

  • Malignant hyperthermia
  • Hepatic toxicity
  • Renal impairment
  • Severe arrhythmias
  • Seizures
  • Anaphylactic reactions

Precautions & Warnings

When using Isoflurane, careful patient assessment and monitoring are essential.

  • Cardiovascular monitoring: observe blood pressure and heart rate for hypotension or tachycardia.
  • Respiratory assessment: ensure airway patency and adequate ventilation.
  • Malignant hyperthermia susceptibility: avoid in patients with known susceptibility.
  • Hepatic function: use cautiously in severe liver disease.
  • Drug interactions: review concomitant medications that may potentiate respiratory depression.
  • Store at ambient temperature: keep container sealed, protect from light and moisture.

Avoid Interactions

Isoflurane can interact with other agents that affect the central nervous system or respiratory function.

Major Interactions (Avoid)

  • Potent CYP2E1 inhibitors (e.g., disulfiram) may increase plasma concentrations.
  • Concurrent use of other inhalational anesthetics can cause additive depressant effects.
  • Opioids or sedatives may lead to profound respiratory depression.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines and other CNS depressants.
  • Monoamine oxidase inhibitors (MAOIs).
  • Anticholinergic agents.
  • Beta‑blockers affecting heart rate control.
  • Nitrous oxide when used in combination.

Frequently Asked Questions

Isofluran Baxter contains isoflurane, an inhalational anesthetic employed to induce and maintain general anesthesia during surgical procedures. It provides rapid loss of consciousness and analgesia, allowing surgeons to perform operations safely.

Isoflurane works by enhancing the activity of the GABA_A receptor, which increases inhibitory neurotransmission in the brain. This depresses neuronal excitability, leading to loss of consciousness, analgesia, and muscle relaxation required for anesthesia.

The dosage of Isofluran Baxter is determined by the prescribing anesthesiologist based on patient characteristics, type of surgery, and monitoring parameters. The prescriber sets the appropriate concentration and delivery rate for each case.

The safety of isoflurane in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential benefits justify any potential risks to the fetus or infant, and under specialist guidance.

To order Isofluran Baxter, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Isoflurane offers a relatively low blood‑gas partition coefficient, providing rapid induction and emergence compared with agents like halothane. It is less irritating than desflurane and has a favorable safety profile, though each anesthetic has unique pharmacokinetic and side‑effect considerations.

Isofluran Baxter should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the solution from direct sunlight, moisture, and extreme temperature fluctuations to maintain stability.

Isofluran Baxter is a solution for inhalation. It is vaporized by an anesthesia machine and delivered to the patient’s airway through a breathing circuit, allowing precise control of concentration during induction and maintenance of anesthesia.

Serious risks include malignant hyperthermia, severe hypotension, cardiac arrhythmias, hepatic or renal toxicity, and rare anaphylactic reactions. Continuous monitoring of cardiovascular and respiratory parameters is essential to detect and manage these events promptly.

Isofluran Baxter should be avoided in patients with known susceptibility to malignant hyperthermia, severe hepatic or renal impairment, uncontrolled cardiovascular disease, or in those who cannot be adequately monitored during anesthesia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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