Product image of Isoflurane Piramal Critical Care (Isoflurane) supplied by GNH India

Isoflurane Piramal Critical Care

Active Ingredient:
Isoflurane
Origin:
EU

Isoflurane Piramal Critical Care (Isoflurane)

Isoflurane, the active ingredient in Isoflurane Piramal Critical Care, is an inhalational anesthetic presented as a volatile liquid for inhalation use. It is employed to induce and maintain a state of general anesthesia in surgical and critical‑care settings.
GNH India supplies Isoflurane Piramal Critical Care as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Piramal Critical Care Limited

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Indications & Clinical Uses

Isoflurane is used in the anesthetic pathway to provide rapid and controllable loss of consciousness for surgical procedures.

  • Induction of general anesthesia: produces quick unconsciousness to begin operative interventions.
  • Maintenance of general anesthesia: sustains unconsciousness and analgesia throughout the procedure.
  • Controlled ventilation support: facilitates mechanical ventilation in critical‑care patients requiring anesthetic depth.

How It Works

  • Isoflurane potentiates the activity of the GABA_A receptor, enhancing inhibitory neurotransmission, while simultaneously inhibiting NMDA receptors, leading to central nervous system depression. This combined effect reduces neuronal excitability, resulting in loss of consciousness, analgesia, and muscle relaxation required for surgical anesthesia.

Side Effects

Isoflurane may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Cough or airway irritation during administration.
  • Nausea or vomiting during emergence.
  • Hypotension due to vasodilation.
  • Tachycardia or transient arrhythmias.
  • Dry mouth or sore throat.
  • Lightheadedness on awakening.

Serious or Rare Side Effects

  • Malignant hyperthermia in susceptible individuals.
  • Severe hepatic dysfunction or jaundice.
  • Profound hypotension unresponsive to fluids.
  • Cardiac arrhythmias requiring intervention.
  • Respiratory depression persisting after discontinuation.
  • Anaphylactoid reactions with bronchospasm.

Precautions & Warnings

Isoflurane administration requires careful monitoring and specific safety measures.

  • Patient monitoring: continuous cardiovascular and respiratory observation is essential.
  • Airway management: secure airway before initiating inhalation.
  • Sensitivity: avoid in patients with known hypersensitivity to volatile anesthetics.
  • Organ function: use cautiously in hepatic or renal impairment.
  • Pregnancy: limited data; weigh benefits against potential risks.
  • Store at ambient temperature: keep container sealed, protect from light and heat, store below 25°C.

Avoid Interactions

Isoflurane can interact with other agents, altering its safety profile.

Major Interactions (Avoid)

  • Halothane: additive hepatotoxic potential.
  • Sodium channel blockers (e.g., lidocaine): increased central nervous system depression.
  • Monoamine oxidase inhibitors: unpredictable cardiovascular effects.

Moderate Interactions (Monitor Closely)

  • Opioids: enhanced respiratory depression.
  • Benzodiazepines: additive sedative effect.
  • Beta‑blockers: may potentiate hypotensive response.

Frequently Asked Questions

Isoflurane Piramal Critical Care is an inhalational anesthetic used to induce and maintain a state of general anesthesia during surgical procedures and in critical‑care settings where controlled ventilation is required.

Isoflurane enhances the inhibitory action of GABA_A receptors and blocks excitatory NMDA receptors in the central nervous system. This dual action depresses neuronal activity, leading to loss of consciousness, analgesia, and muscle relaxation necessary for anesthesia.

The specific dose and concentration of isoflurane are determined by the prescribing anesthesiologist based on the patient’s age, weight, medical condition, and the type of procedure. Dosing is individualized and adjusted during the anesthetic course.

Safety data for isoflurane in pregnancy and lactation are limited. It should only be used when the potential benefits justify any possible risk to the fetus or infant, and decisions are made by the treating physician in consultation with obstetric specialists.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Isoflurane offers a rapid onset and relatively low blood‑gas solubility, allowing quick adjustment of anesthetic depth. Compared with agents like sevoflurane, it may have a slightly higher pungency but is cost‑effective and provides stable cardiovascular profiles in many patients.

Isoflurane should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from direct sunlight, excessive heat, and moisture to maintain potency and safety.

Isoflurane is delivered via a calibrated vaporizer attached to a breathing circuit. The anesthesiologist controls the vaporizer setting to achieve the desired concentration, while continuously monitoring the patient’s vital signs and airway status.

Serious risks include malignant hyperthermia, severe hypotension, significant hepatic injury, and persistent respiratory depression after discontinuation. Prompt recognition and appropriate emergency management are essential to mitigate these complications.

Isoflurane is contraindicated in patients with known hypersensitivity to volatile anesthetics, those with a history of malignant hyperthermia, and individuals where the risks outweigh the benefits, such as certain severe hepatic disorders, unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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