Product image of Isoket (Isosorbide Dinitrate) supplied by GNH India

Isoket

Active Ingredient:
Isosorbide Dinitrate
Origin:
EU

Isoket (Isosorbide Dinitrate)

Isosorbide dinitrate, the active ingredient in Isoket, is an organic nitrate presented as an intravenous solution for intravenous use. It treats angina pectoris and heart failure in adult patients.

GNH India supplies Isoket as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Merus Labs Luxco Ii S.À R.L.

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Indications & Clinical Uses

  • Isosorbide dinitrate is used in the management of cardiovascular conditions that increase myocardial oxygen demand.
  • Angina pectoris: reduces the frequency and severity of chest pain episodes.
  • Heart failure: improves symptoms and exercise tolerance in chronic heart failure.
  • Prevention of angina attacks: provides prophylactic relief when administered before exertion.

How It Works

  • Isosorbide dinitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous smooth muscle, producing vasodilation, reduced preload and afterload, and consequently lower myocardial oxygen consumption.

Side Effects

Isosorbide dinitrate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: throbbing or pressure headache.
  • Flushing: warmth and redness of the face or neck.
  • Hypotension: noticeable drop in blood pressure causing dizziness.
  • Tachycardia: rapid heart rate.
  • Nausea: feeling of queasiness or upset stomach.
  • Peripheral edema: swelling of the lower limbs.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure leading to fainting.
  • Methemoglobinemia: abnormal hemoglobin causing cyanosis.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Reflex tachycardia: rapid heart rate in response to blood pressure fall.

Precautions & Warnings

  • When using Isoket, clinicians should consider several safety measures.
  • Avoid abrupt discontinuation: may precipitate rebound angina.
  • Monitor blood pressure: especially in patients with baseline hypotension.
  • Assess cardiac status: in severe heart failure or recent myocardial infarction.
  • Use with caution in elderly: increased sensitivity to vasodilatory effects.
  • Avoid concomitant phosphodiesterase‑5 inhibitors: risk of profound hypotension.
  • Store at below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Isosorbide dinitrate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause severe hypotension.
  • Other nitrates or nitric oxide donors: additive vasodilatory effect leading to dangerous blood pressure drops.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, beta‑blockers): may enhance blood pressure lowering.
  • Diuretics: can increase risk of orthostatic hypotension.
  • Alcohol: may potentiate vasodilatory response.
  • Certain antibiotics (e.g., macrolides): may affect metabolism and plasma levels.

Frequently Asked Questions

Isoket, containing isosorbide dinitrate, is indicated for the treatment of angina pectoris and for symptom relief in chronic heart failure. It helps reduce chest pain episodes and improves exercise tolerance by lowering myocardial oxygen demand.

Isosorbide dinitrate releases nitric oxide after metabolic conversion. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels, which relax vascular smooth muscle. This vasodilation decreases preload and afterload, reducing the workload on the heart and alleviating angina.

The specific dose of Isoket is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage regimens are individualized and should follow the prescriber’s instructions and local clinical guidelines.

Safety data for isosorbide dinitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Isoket, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any required import documentation.

Isoket belongs to the organic nitrate class, which provides rapid vasodilation. Compared with beta‑blockers or calcium‑channel blockers, nitrates act directly on vascular smooth muscle and are often used for acute relief or prophylaxis, whereas the other classes modify heart rate or contractility.

Isoket should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Maintaining these conditions helps preserve the stability and potency of the intravenous formulation.

Isoket is administered intravenously by a healthcare professional. The solution is typically infused over a short period under clinical monitoring, allowing rapid onset of vasodilatory effects for acute angina relief or heart‑failure management.

The most serious risks include severe hypotension, which can lead to fainting or shock, and rare cases of methemoglobinemia. Patients should be monitored for sudden drops in blood pressure and signs of oxygenation problems during therapy.

Isoket should be avoided in patients with known hypersensitivity to nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24‑48 hours, and individuals with severe hypotension or uncontrolled shock unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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