Product image of Isolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu) supplied by GNH India

Isolyte

Active Ingredient:
Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu
Origin:
EU

Isolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu)

Magnesium chloride hexahydrate, potassium chloride, sodium chloride, calcium chloride dihydrate and glucose, the active ingredients in Isolyte, are an electrolyte solution presented as a solution for injection for intravenous use. It provides fluid and electrolyte replacement in patients requiring rehydration, peri‑operative management or correction of electrolyte disturbances.

GNH India supplies Isolyte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter S.P.A.

1
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Indications & Clinical Uses

Isolyte is an isotonic electrolyte solution used to address fluid and electrolyte deficits across several clinical settings.

  • Fluid replacement: restores intravascular volume and supports hemodynamic stability.
  • Electrolyte replenishment: corrects deficits of sodium, potassium, calcium, magnesium and glucose.
  • Dehydration treatment: rehydrates patients with fluid loss due to illness or surgery.
  • Peri‑operative fluid balance: maintains appropriate fluid status during surgical procedures.

How It Works

  • Isolyte delivers a balanced mixture of sodium, potassium, calcium, magnesium ions and glucose directly into the bloodstream. The isotonic composition equilibrates extracellular fluid osmolarity, while the individual ions are readily taken up by cells, supporting membrane potential, enzymatic activity and metabolic processes, thereby restoring and maintaining normal fluid and electrolyte balance.

Side Effects

Isolyte may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Infusion site irritation or pain.
  • Mild hypernatremia or hyponatremia.
  • Transient hyperkalemia.
  • Slight hypocalcemia.
  • Nausea or mild vomiting.
  • Light‑headedness or mild hypotension.

Serious or Rare Side Effects

  • Severe hypermagnesemia leading to cardiac conduction abnormalities.
  • Life‑threatening hyperkalemia causing arrhythmias.
  • Anaphylactic or severe allergic reaction.
  • Fluid overload with pulmonary edema.
  • Metabolic acidosis.
  • Cardiac arrest due to electrolyte imbalance.

Precautions & Warnings

Before administering Isolyte, consider the following precautions.

  • Renal impairment: monitor electrolyte levels closely.
  • Cardiac disease: assess baseline potassium and magnesium.
  • Pregnancy: use only if clearly needed after risk‑benefit evaluation.
  • Concomitant electrolyte supplements: avoid duplicate dosing.
  • Infusion rate: follow prescribed rate to prevent rapid shifts.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Isolyte can interact with other medications that affect electrolyte balance.

Major Interactions (Avoid)

  • ACE inhibitors: increased risk of hyperkalemia.
  • Potassium‑sparing diuretics: additive potassium load.
  • Loop diuretics: may exacerbate electrolyte disturbances.
  • Magnesium‑containing antacids: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Insulin therapy: may cause rapid intracellular potassium shift.
  • Beta‑agonists: can lower serum potassium.
  • Blood transfusions: citrate may bind calcium, altering calcium levels.

Frequently Asked Questions

Isolyte is an intravenous electrolyte solution indicated for fluid replacement, electrolyte replenishment, treatment of dehydration, and maintenance of fluid balance during surgery or other medical procedures that require careful management of electrolytes and volume status.

The combination of magnesium chloride, potassium chloride, sodium chloride, calcium chloride and glucose provides an isotonic mixture that quickly restores extracellular fluid osmolarity and supplies essential ions needed for cellular function, nerve conduction, muscle contraction and metabolic processes.

The dose of Isolyte is individualized. The prescribing clinician determines the volume and infusion rate based on the patient’s fluid status, electrolyte levels, weight, and clinical condition. No fixed regimen is provided in public information.

Safety data for Isolyte in pregnancy and lactation are limited. It should be used only when clearly needed and after a careful risk‑benefit assessment by the treating physician.

To order Isolyte, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Isolyte contains a broader electrolyte profile—including magnesium and calcium—compared with normal saline, which provides only sodium and chloride. Compared with lactated Ringer’s, Isolyte adds glucose for energy and a higher magnesium content, making it suitable for patients needing both electrolyte and caloric support.

Isolyte should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the container in its original packaging and handle with aseptic technique to maintain sterility before intravenous administration.

Isolyte is administered intravenously as a sterile solution for injection. The infusion is given through a calibrated IV set, following the rate and volume prescribed by the healthcare professional, typically using an infusion pump for precise control.

Serious risks include severe hypermagnesemia or hyperkalemia that can cause cardiac arrhythmias, anaphylactic reactions, fluid overload leading to pulmonary edema, and metabolic disturbances such as acidosis. Immediate medical attention is required if any of these occur.

Isolyte is contraindicated in patients with known hypersensitivity to any of its components, severe hyperkalemia, severe hypermagnesemia, uncontrolled heart failure, or those for whom rapid fluid shifts could be hazardous. Clinical judgment should guide use in other high‑risk populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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