Product image of Isolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate) supplied by GNH India

Isolyte

Active Ingredient:
Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate
Origin:
EU

Isolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate)

Magnesium chloride hexahydrate, potassium chloride, sodium chloride and sodium acetate trihydrate, the active ingredients in Isolyte, are an electrolyte solution presented as a solution for injection for intravenous use. It provides isotonic fluid and essential electrolytes to support fluid balance and correct electrolyte disturbances in surgical, critical‑care and dehydrated patients.

GNH India supplies Isolyte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Fresenius Kabi S.R.O.

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Indications & Clinical Uses

Isolyte is an intravenous electrolyte solution used to manage fluid and electrolyte disorders in various clinical settings.

  • Maintenance of fluid balance during surgery or critical care: restores plasma volume and maintains hemodynamic stability.
  • Treatment of dehydration and hypovolemia: supplies isotonic fluid to re‑hydrate patients.
  • Correction of electrolyte disturbances (e.g., hyponatremia, hypokalemia, hypomagnesemia): delivers magnesium, potassium, sodium and acetate to normalize serum levels.

How It Works

  • Isolyte delivers magnesium, potassium, sodium and acetate ions in an isotonic carrier, expanding the extracellular fluid compartment. The solution raises plasma volume, thereby improving tissue perfusion, while the supplied electrolytes replenish deficits and help re‑establish normal cellular membrane potentials and acid‑base balance.

Side Effects

Adverse reactions may occur with any intravenous electrolyte preparation.

Common Side Effects

  • Infusion site pain or irritation.
  • Mild hyperkalemia.
  • Mild hypermagnesemia.
  • Mild hyponatremia.
  • Transient hypotension.
  • Nausea.

Serious or Rare Side Effects

  • Severe hyperkalemia leading to cardiac arrhythmia.
  • Severe hypermagnesemia causing respiratory depression.
  • Anaphylactic or severe allergic reaction.
  • Cardiac arrhythmias unrelated to electrolyte levels.
  • Fluid overload with pulmonary edema.
  • Severe hypotension requiring intervention.

Precautions & Warnings

Careful assessment and monitoring are required when using Isolyte.

  • Baseline electrolyte assessment: verify serum Na+, K+, Mg2+ before infusion.
  • Cardiac monitoring: observe rhythm during and after administration.
  • Adjust infusion rate in renal impairment to avoid accumulation.
  • Caution in heart failure: monitor for signs of fluid overload.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Isolyte may interact with other medications affecting electrolyte balance.

Major Interactions (Avoid)

  • Concurrent potassium‑sparing diuretics: risk of hyperkalemia.
  • Co‑administration with other magnesium‑containing products: risk of hypermagnesemia.
  • Simultaneous infusion of high‑sodium IV fluids: risk of fluid overload.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may influence serum calcium dynamics.
  • ACE inhibitors or ARBs: can potentiate potassium shifts.
  • Loop diuretics: may increase loss of electrolytes, requiring closer monitoring.

Frequently Asked Questions

Isolyte is an intravenous electrolyte solution used to restore fluid volume and correct electrolyte imbalances in patients undergoing surgery, receiving critical‑care support, or experiencing dehydration and hypovolemia.

The combination of magnesium, potassium, sodium and acetate ions in Isolyte expands the extracellular fluid space, replenishes deficient electrolytes, and helps maintain acid‑base balance, thereby supporting normal cellular function and circulatory stability.

The prescribed dose of Isolyte is determined by the treating clinician based on the patient’s fluid status, electrolyte levels, weight, and clinical condition. Dosing is individualized and should follow the prescriber’s instructions.

Safety data for Isolyte in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Isolyte, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isolyte differs from plain saline or dextrose solutions by containing magnesium, potassium, sodium and acetate, making it suitable for patients who need both volume expansion and electrolyte replacement, whereas standard crystalloids provide only sodium and chloride.

Isolyte should be stored at ambient temperature, kept in its original packaging, protected from moisture and direct sunlight, and used before the expiration date indicated on the label.

Isolyte is administered intravenously by infusion. The rate and volume are set by the prescribing clinician, typically using an infusion pump or controlled drip to match the patient’s fluid and electrolyte needs.

Serious risks include severe hyperkalemia or hypermagnesemia, which can cause cardiac arrhythmias, respiratory depression, and anaphylactic reactions. Monitoring of electrolyte levels and cardiac status is essential during therapy.

Isolyte should be avoided in patients with known hypersensitivity to any component, uncontrolled hyperkalemia or hypermagnesemia, severe fluid overload, or in those for whom the electrolyte composition is contraindicated without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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