Product image of Isomol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Isomol

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Isomol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Sodium hydrogen carbonate, potassium chloride, sodium chloride and macrogol 3350, the active ingredients in Isomol, are an electrolyte and osmotic laxative preparation presented as an oral solution for oral use. It is used to cleanse the bowel and manage constipation in adults.

GNH India supplies Isomol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Norgine Healthcare B.V.

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Indications & Clinical Uses

Isomol is employed in gastrointestinal preparation and electrolyte management.

  • Bowel preparation for colonoscopy: facilitates cleansing of the intestinal tract before endoscopic procedures.
  • Constipation management: provides osmotic water retention to soften stool and promote bowel movements.
  • Electrolyte replacement: restores sodium and potassium balance in patients with mild dehydration.

How It Works

  • Isomol works by combining an osmotic laxative (macrogol 3350) that retains water in the intestinal lumen with electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) that adjust osmolarity and provide buffering capacity. The increased intraluminal fluid softens stool and stimulates peristalsis, while the salts help maintain electrolyte homeostasis during the cleansing process.

Side Effects

Adverse reactions may occur with oral electrolyte and laxative solutions.

Common Side Effects

  • Abdominal bloating: feeling of fullness or distension.
  • Nausea: mild queasiness during intake.
  • Flatulence: increased intestinal gas.
  • Mild electrolyte disturbance: transient changes in serum sodium or potassium.
  • Thirst: increased desire for fluids.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss requiring medical attention.
  • Significant electrolyte imbalance: hypernatremia or hypokalemia.
  • Allergic reaction: rash, itching, or angioedema.
  • Renal impairment: worsening kidney function in susceptible individuals.
  • Severe abdominal pain: may indicate complications.
  • Colonic perforation: extremely rare but serious gastrointestinal injury.

Precautions & Warnings

Use Isomol with appropriate clinical assessment and monitoring.

  • Assess renal function: avoid in severe renal impairment.
  • Monitor electrolytes: check serum sodium and potassium before and during therapy.
  • Avoid in bowel obstruction: contraindicated when mechanical blockage is present.
  • Use with caution in elderly: increased risk of dehydration.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isomol may interact with other medications affecting fluid and electrolyte balance.

Major Interactions (Avoid)

  • Loop diuretics: may exacerbate electrolyte loss.
  • Lithium: risk of altered lithium levels.
  • ACE inhibitors: increased risk of hyperkalemia.
  • Antacids containing sodium bicarbonate: additive sodium load.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may affect renal function.
  • Corticosteroids: increase risk of fluid imbalance.
  • Oral rehydration solutions: potential overlapping electrolyte content.

Frequently Asked Questions

Isomol is an oral solution that combines electrolytes and an osmotic laxative. It is primarily used to prepare the bowel for procedures such as colonoscopy and to relieve occasional constipation by softening stool and promoting bowel movements.

The macrogol 3350 component acts as an osmotic agent, drawing water into the intestinal lumen, while the sodium hydrogen carbonate, potassium chloride and sodium chloride provide electrolytes that maintain fluid balance and buffer intestinal pH. Together they facilitate bowel cleansing and stool softening.

The dosage of Isomol is determined by the prescribing healthcare professional based on the indication, patient age, weight and clinical condition. Patients should follow the exact instructions provided by their prescriber and not alter the dose on their own.

Safety of Isomol in pregnancy or while breastfeeding has not been fully established. Women who are pregnant, planning a pregnancy, or nursing should discuss potential risks and benefits with their healthcare provider before using this product.

To order Isomol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isomol combines electrolyte salts with macrogol 3350, offering both bowel cleansing and electrolyte replacement in a single formulation. Compared with pure polyethylene‑glycol solutions, it may provide better fluid balance, while differing from sodium‑phosphate preparations that carry higher risks of renal complications.

Isomol should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the container from moisture, direct sunlight and extreme temperatures to maintain product stability.

Isomol is taken orally as directed by a healthcare professional, usually mixed with a specified volume of water and consumed in divided doses. It should be ingested according to the prescribed schedule to achieve effective bowel preparation.

Serious risks include severe dehydration, significant electrolyte disturbances such as hypernatremia or hypokalemia, allergic reactions, renal impairment, and, in rare cases, colonic perforation. Patients should seek immediate medical attention if they experience severe abdominal pain, persistent vomiting, or signs of electrolyte imbalance.

Isomol should be avoided in individuals with known hypersensitivity to any component, severe renal insufficiency, bowel obstruction, or those on medications that could cause dangerous electrolyte shifts without close monitoring. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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