Product image of Isoniazid -100 (Isoniazid ) 100mg Tablet supplied by GNH India

Isoniazid -100

Active Ingredient:
Isoniazid
Form:
Tablet
Brand:
Isoniazid -100
Origin:
India

Isoniazid -100 (Isoniazid Tablet) 100mg

Isoniazid, the active ingredient in Isoniazid -100, is an antitubercular agent presented as a 100mg tablet for oral use. It is used to treat active tuberculosis and to prevent latent tuberculosis infection in patients who may be at risk.

GNH India supplies Isoniazid -100 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

100mg

Pack Size

100s

Storage

Ambient

Manufacturer / TM Owner

Care Formulation Labs

1
Pack/s
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Indications & Clinical Uses

Isoniazid -100 is an antitubercular agent used to treat tuberculosis and prevent latent tuberculosis infection.

  • Active tuberculosis: Treats active infections caused by Mycobacterium tuberculosis.
  • Latent tuberculosis infection: Prevents the development of active tuberculosis in individuals who are infected but not yet symptomatic.
  • Tuberculosis prophylaxis: Used in combination with other drugs to prevent tuberculosis in high-risk populations.

How It Works

  • Isoniazid works by inhibiting the synthesis of mycolic acids, which are essential components of the mycobacterial cell wall. It is a prodrug activated by the mycobacterial enzyme KatG (catalase-peroxidase) to an isonicotinoyl radical, which then inhibits InhA (enoyl-ACP reductase), a key enzyme in mycolic acid biosynthesis. This disruption leads to cell wall destruction and bactericidal activity against Mycobacterium tuberculosis.

Side Effects

Isoniazid -100 may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea
  • Dizziness
  • Peripheral neuropathy
  • Elevated liver enzymes
  • Vomiting
  • Epigastric discomfort

Serious or Rare Side Effects

  • Hepatotoxicity or fulminant hepatic failure
  • Peripheral neuropathy (reduced by pyridoxine supplementation)
  • Drug-induced lupus (ANA positive, arthralgia, rash)
  • CNS effects: dizziness, memory impairment, seizures
  • Agranulocytosis, thrombocytopenia

Precautions & Warnings

Isoniazid -100 should be used with caution and under medical supervision.

  • Monitoring: Regular monitoring of liver function tests (LFTs) is essential, especially in high-risk patients.
  • Pyridoxine supplementation: Co-supplementation with pyridoxine (Vitamin B6) is recommended to prevent peripheral neuropathy.
  • Alcohol consumption: Avoid alcohol as it significantly increases the risk of hepatotoxicity.
  • Pregnancy: Use with caution and in combination with pyridoxine during pregnancy.
  • Storage: Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Isoniazid -100 may interact with other medications, which can affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

  • Rifampicin: May reduce the effectiveness of isoniazid.
  • Carbamazepine: May increase the risk of seizures.
  • Phenytoin: May reduce the effectiveness of phenytoin.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: May increase the risk of bleeding.
  • Oral contraceptives: May reduce the effectiveness of oral contraceptives.
  • Antiretroviral drugs: May increase the risk of hepatotoxicity.

Frequently Asked Questions

Isoniazid -100 is used to treat active tuberculosis and to prevent latent tuberculosis infection. It is effective against Mycobacterium tuberculosis and is often used in combination with other antitubercular drugs.

Isoniazid works by inhibiting the synthesis of mycolic acids, which are essential components of the mycobacterial cell wall. It is activated by the mycobacterial enzyme KatG to an isonicotinoyl radical, which then inhibits InhA, a key enzyme in mycolic acid biosynthesis, leading to cell wall destruction and bactericidal activity.

The usual dose of Isoniazid -100 is determined by a healthcare professional based on the patient's condition, age, and weight. It is typically taken once daily or three times weekly, depending on the treatment regimen.

Isoniazid -100 can be used during pregnancy but should be taken in combination with pyridoxine (Vitamin B6) to prevent peripheral neuropathy. The benefits of treating tuberculosis during pregnancy generally outweigh the potential risks.

To order Isoniazid -100 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Isoniazid -100 is a first-line antitubercular agent often used in combination with other drugs like rifampicin, pyrazinamide, and ethambutol. It is effective and well-tolerated by most patients, but its use requires regular monitoring of liver function and pyridoxine supplementation to prevent side effects.

Isoniazid -100 should be stored below 25°C, in the original pack, and protected from moisture. Proper storage ensures the medication remains effective and safe for use.

Isoniazid -100 is administered orally, typically taken once daily or three times weekly as prescribed by a healthcare professional. It should be taken 30 minutes before food for optimal absorption.

The most serious risks associated with Isoniazid -100 include hepatotoxicity, peripheral neuropathy, drug-induced lupus, and CNS effects such as seizures. Regular monitoring of liver function and pyridoxine supplementation can help mitigate these risks.

Isoniazid -100 should not be used by individuals with a history of severe adverse reactions to isoniazid, such as isoniazid-associated hepatic injury. It should be used with caution in patients with liver disease, alcohol use disorder, and those who are slow acetylators.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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