Product image of Isoniazida Labesfal (Isoniazid) supplied by GNH India

Isoniazida Labesfal

Active Ingredient:
Isoniazid
Origin:
EU

Isoniazida Labesfal (Isoniazid)

Isoniazid, the active ingredient in Isoniazida Labesfal, is an antitubercular agent presented as an oral dosage form for oral use. It is employed in the treatment of active tuberculosis and in the prevention of latent tuberculosis infection in at‑risk individuals.

GNH India supplies Isoniazida Labesfal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured products that meet EU regulatory standards and facilitating reliable access across multiple regions.

Manufacturer / TM Owner

Labesfal Laboratorios Almiro, S.A.

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Indications & Clinical Uses

Isoniazid is used in antitubercular therapy to target Mycobacterium tuberculosis infection.

  • Active tuberculosis: eradicates replicating Mycobacterium tuberculosis, contributing to cure of pulmonary and extrapulmonary disease.
  • Latent tuberculosis infection: reduces risk of progression to active disease in individuals with positive tuberculin test or recent exposure.
  • Preventive therapy in high‑risk contacts: provides chemoprophylaxis for persons exposed to contagious TB cases.

How It Works

  • Isoniazid inhibits the synthesis of mycolic acids, essential components of the mycobacterial cell wall, by targeting the enzyme InhA. This blockade prevents cell‑wall formation, leading to death of actively replicating Mycobacterium tuberculosis organisms.

Side Effects

Isoniazid may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Hepatotoxicity: transient elevation of liver enzymes.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Severe hepatitis: jaundice, abdominal pain, dark urine.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Anaphylaxis: acute allergic reaction with airway compromise.

Precautions & Warnings

Before initiating therapy, several precautions should be observed.

  • Liver function monitoring: assess baseline transaminases and repeat during therapy.
  • Vitamin B6 supplementation: consider pyridoxine to reduce neuropathy risk.
  • Alcohol consumption: avoid or limit alcohol due to increased hepatotoxicity risk.
  • Pregnancy and lactation: use only if benefits outweigh potential risks; consult healthcare provider.
  • Drug resistance: ensure susceptibility testing to prevent emergence of resistant Mycobacterium strains.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and light.

Avoid Interactions

Isoniazida Labesfal can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Rifampicin: reduces isoniazid plasma levels, compromising efficacy.
  • Anticonvulsants (e.g., phenytoin, carbamazepine): increase hepatic metabolism, lowering drug exposure.
  • Alcohol: synergistic hepatotoxic effect, heightening liver injury risk.

Moderate Interactions (Monitor Closely)

  • Acetylhydrazine‑containing drugs: may increase risk of hepatotoxicity.
  • Sulfonamides: potential additive liver toxicity.
  • Warfarin: may alter INR, requiring closer coagulation monitoring.

Frequently Asked Questions

Isoniazida Labesfal contains isoniazid, an antitubercular medication prescribed for the treatment of active tuberculosis disease and for chemoprophylaxis of latent tuberculosis infection in individuals at risk. It is part of standard multidrug regimens recommended by WHO and national TB programs.

Isoniazid inhibits the synthesis of mycolic acids, which are essential components of the mycobacterial cell wall. By blocking the enzyme InhA, it prevents cell‑wall formation, leading to bacterial death, particularly against actively replicating Mycobacterium tuberculosis organisms.

The dosage of Isoniazida Labesfal is determined by the prescribing clinician based on patient weight, age, disease status, and renal or hepatic function. Healthcare providers follow national guidelines to set an appropriate daily dose and treatment duration.

Isoniazid is classified as a pregnancy‑category drug where benefits may outweigh potential risks. It can be used when the mother has active or latent TB, but clinicians usually prescribe pyridoxine to reduce neuropathy risk. Breastfeeding is generally considered acceptable under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isoniazid is a first‑line agent with high early bactericidal activity, often combined with rifampicin, pyrazinamide and ethambutol. Alternatives such as rifampicin or fluoroquinolones may be used when resistance occurs, but isoniazid remains preferred for its potency, oral administration, and cost‑effectiveness in susceptible strains.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Isoniazida Labesfal is taken orally, usually once daily on an empty stomach to improve absorption. Patients should swallow the tablet with a full glass of water and follow the prescribing clinician’s instructions regarding timing relative to meals and other medications.

The most serious adverse events include severe hepatitis, which may present with jaundice and abdominal pain, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Prompt medical evaluation is essential if these symptoms occur during therapy.

Individuals with known hypersensitivity to isoniazid or any excipients, patients with pre‑existing severe liver disease, and those with certain metabolic deficiencies (e.g., severe G6PD deficiency) should avoid the medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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