Isoniazide Costero (Isoniazid)

Isoniazid is a pro‑drug that is activated inside Mycobacterium tuberculosis by the bacterial enzyme KatG. The activated form blocks the synthesis of mycolic acids, which are essential components of the bacterial cell wall, leading to rapid bactericidal killing of the organism.

The dosage of isoniazid is individualized by the prescribing clinician based on factors such as patient age, weight, renal function, and whether the drug is being used for active disease or prophylaxis. Standard adult regimens typically range from 5 mg/kg to 10 mg/kg per day, but the exact amount must be set by a qualified prescriber.

Safety data for isoniazid in pregnancy and lactation are limited. The drug may be used when the expected benefit outweighs potential risks, and pyridoxine supplementation is recommended to reduce the risk of neuropathy. Breastfeeding mothers should consult their healthcare provider, as isoniazid does pass into breast milk in small amounts.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative in first‑line tuberculosis therapy is rifampicin, which has a different mechanism— inhibition of bacterial RNA synthesis. Isoniazid is bactericidal against actively replicating bacilli, while rifampicin is also bactericidal but works on a broader range of bacterial species. Both are used together to enhance efficacy and prevent resistance.

Store the product at room temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and excessive heat. Keep the container tightly closed and out of reach of children. No special refrigeration is required for this oral tablet formulation.

Isoniazide Costero is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a full glass of water. Patients are advised to follow the exact schedule provided by their healthcare professional to maintain consistent drug levels.

The most serious adverse events include severe hepatitis, which may present with jaundice, fatigue, or dark urine, and neurological complications such as peripheral neuropathy or, rarely, seizures. Any signs of liver dysfunction or unusual neurological symptoms should prompt immediate medical evaluation.

Isoniazide Costero should be avoided in individuals with known hypersensitivity to isoniazid or any of its excipients. Caution is also required for patients with pre‑existing liver disease, severe renal impairment, or those taking medications that strongly interact with isoniazid without appropriate monitoring.