Product image of Isonly (Isoprenaline Hydrochloride) supplied by GNH India

Isonly

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isonly (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isonly, is a beta‑adrenergic agonist presented as an injectable solution for intravenous use. It is employed to raise heart rate and improve myocardial contractility in patients with bradycardia, heart block, asystole, cardiac arrest, and to relieve bronchospasm in acute respiratory distress.
GNH India supplies Isonly as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Isonly, a non‑selective beta‑adrenergic agonist, is used in acute cardiovascular and respiratory emergencies.

  • Bradycardia: increases heart rate to restore adequate cardiac output.
  • Heart block: enhances atrioventricular conduction to improve rhythm stability.
  • Asystole: provides rapid chronotropic stimulation during cardiac arrest.
  • Cardiac arrest: supports circulatory resuscitation by boosting myocardial contractility.
  • Bronchospasm: induces bronchodilation to ease airway obstruction in emergency settings.

How It Works

  • Isoprenaline Hydrochloride binds to both β1 and β2 adrenergic receptors, activating adenylate cyclase and raising intracellular cyclic AMP. The rise in cAMP enhances calcium influx in cardiac myocytes, increasing heart rate (positive chronotropy) and contractile force (positive inotropy). Simultaneously, β2‑receptor activation relaxes bronchial smooth muscle, producing bronchodilation. These combined actions support hemodynamic stability and airway patency during acute events.

Side Effects

Isonly may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Tachycardia: excessively rapid heart rate.
  • Palpitations: sensation of irregular or forceful beats.
  • Headache: mild to moderate cranial discomfort.
  • Tremor: fine muscle shaking, especially in the hands.
  • Nausea: feeling of queasiness or urge to vomit.
  • Hyperglycemia: transient rise in blood glucose levels.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening irregular heart rhythms.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Anaphylaxis: acute allergic reaction requiring immediate intervention.

Precautions & Warnings

When using Isonly, clinicians should observe several safety measures to minimise risk.

  • Cardiac monitoring: continuously assess heart rhythm and rate during infusion.
  • Dose titration: adjust infusion speed based on hemodynamic response.
  • Contraindications: avoid in patients with uncontrolled ventricular tachyarrhythmias.
  • Caution in ischemic heart disease: monitor for signs of myocardial oxygen demand exceeding supply.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Isonly can interact with other agents that affect cardiovascular function or catecholamine metabolism.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt the chronotropic and inotropic effects of isoprenaline.
  • Class III antiarrhythmics (e.g., amiodarone): increase risk of severe arrhythmias.
  • MAO inhibitors: can potentiate catecholamine‑related toxicity.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance negative inotropic effects.
  • Diuretics: can exacerbate electrolyte disturbances, especially hypokalemia.
  • Antihypertensives: may require dose adjustments to maintain target blood pressure.

Frequently Asked Questions

Isonly is indicated for acute management of bradycardia, heart block, asystole, cardiac arrest, and severe bronchospasm. In each case the drug works to increase heart rate, improve myocardial contractility, or relax airway smooth muscle, providing rapid physiological support in emergency settings.

Isoprenaline Hydrochloride is a non‑selective β‑adrenergic agonist. It binds to β1 receptors in the heart to raise cyclic AMP, which speeds the heart rate and strengthens contractions. It also stimulates β2 receptors in the lungs, causing bronchodilation by relaxing airway smooth muscle.

The dosage of Isonly is determined by the prescribing clinician based on the patient’s clinical condition, weight, and response. Dosing is individualized and administered intravenously under continuous monitoring in a hospital or emergency environment.

Safety data for Isonly in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Isonly, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Isonly (isoprenaline) differs from agents such as epinephrine or dopamine by being a non‑selective β‑agonist with strong chronotropic and bronchodilatory effects but minimal α‑mediated vasoconstriction. This profile makes it useful when rapid heart‑rate increase and airway relaxation are desired, whereas other drugs may provide more vasoconstrictive support.

Isonly should be stored at 2‑8 °C in a refrigerator, protected from light. The vial must not be frozen or shaken, and it should remain in its original packaging until ready for use to maintain stability and potency.

Isonly is given intravenously, typically as a continuous infusion or rapid bolus, depending on the clinical scenario. Administration is performed by trained healthcare professionals in a setting where cardiac monitoring and emergency support are available.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and anaphylactic reactions. Continuous cardiac and hemodynamic monitoring is essential to detect and manage these complications promptly.

Isonly is contraindicated in patients with uncontrolled ventricular tachyarrhythmias, severe ischemic heart disease, or known hypersensitivity to isoprenaline. Caution is also advised for individuals on beta‑blockers or other agents that may interfere with its pharmacologic action.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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