Product image of Isoplasmal G (Valine, Ornithine Hydrochloride, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, ) supplied by GNH India

Isoplasmal G

Active Ingredient:
Valine, Ornithine Hydrochloride, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine,
Origin:
EU

Isoplasmal G (Valine, Ornithine Hydrochloride, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine,)

Valine, the active ingredient in Isoplasmal G, is an amino acid presented as an intravenous solution for parenteral use. It supports protein synthesis and metabolic functions in patients requiring nutritional support.\n\nGNH India supplies Isoplasmal G as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Medical, S.A.

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Indications & Clinical Uses

  • Isoplasmal G is used as a parenteral amino acid formulation to address nutritional and metabolic needs in clinical settings.\n\nParenteral nutrition: provides essential amino acids to support protein synthesis in patients unable to eat orally.\nHepatic support: supplies substrates such as ornithine and acetylcysteine that aid detoxification pathways in liver dysfunction.\nCatabolic states: delivers a balanced amino acid profile to mitigate muscle loss during severe illness or trauma.

How It Works

  • Isoplasmal G delivers a balanced mixture of essential and conditionally essential amino acids directly into the bloodstream. The amino acids are taken up by cells and incorporated into proteins, supporting tissue repair and synthesis. Ornithine participates in the urea cycle, facilitating ammonia clearance, while acetylcysteine contributes to glutathione production, enhancing antioxidant defenses. Together, these components help restore metabolic balance in patients receiving intravenous nutrition.

Side Effects

  • Adverse reactions may occur with any intravenous amino acid solution. Monitoring during infusion is recommended.\n\nCommon Side Effects:\n- Mild infusion site erythema or pain\n- Transient nausea or vomiting\n- Slight increase in serum ammonia levels\n- Mild headache\n- Temporary elevation of liver enzymes\n\nSerious or Rare Side Effects:\n- Anaphylactic or severe hypersensitivity reaction\n- Acute renal impairment\n- Significant electrolyte disturbances\n- Severe metabolic acidosis\n- Thrombophlebitis at the infusion site

Precautions & Warnings

  • Isoplasmal G should be administered under medical supervision with appropriate monitoring.\n\nAssess renal and hepatic function before initiation: adjust infusion rate if impairment is present.\nMonitor serum electrolytes and ammonia during therapy: intervene if values deviate from normal range.\nAvoid concurrent administration of incompatible IV drugs: flush line between infusions.\nUse aseptic technique to prevent contamination: inspect solution for particulates before use.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Potential drug interactions may modify the safety or efficacy of Isoplasmal G.\n\nMajor Interactions (Avoid):\n- Concurrent use of high‑dose acetylcysteine with other sulfhydryl‑containing agents: risk of additive toxicity.\n- Co‑administration with nephrotoxic drugs (e.g., aminoglycosides): may exacerbate renal impairment.\n\nModerate Interactions (Monitor Closely):\n- Loop diuretics: may increase electrolyte loss, requiring closer monitoring.\n- Anticoagulants (e.g., heparin): amino acids can affect plasma protein binding, altering anticoagulant effect.\n- Other parenteral nutrition components: ensure compatible mixing to avoid precipitation.

Frequently Asked Questions

Isoplasmal G is an intravenous amino acid solution used to provide essential nutrients for patients who cannot receive nutrition orally. It supports protein synthesis, assists liver detoxification pathways, and helps maintain metabolic balance in clinical situations such as parenteral nutrition, hepatic support, and severe catabolic states.

Valine, together with other amino acids in Isoplasmal G, is taken up by cells and incorporated into proteins, promoting tissue repair and growth. It also participates in nitrogen transport and energy metabolism, contributing to overall metabolic stability when delivered directly into the bloodstream.

The dose of Isoplasmal G is determined by the prescribing clinician based on the patient’s weight, clinical condition, and nutritional requirements. Healthcare professionals calculate the appropriate infusion rate and total volume to meet individual therapeutic goals.

Safety data for Isoplasmal G in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Isoplasmal G, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Isoplasmal G offers a comprehensive blend of essential and conditionally essential amino acids, including ornithine and acetylcysteine, which are not always present in standard formulations. This broader profile may provide added benefits for hepatic support and antioxidant capacity compared with simpler amino acid mixtures.

Isoplasmal G must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before administration, inspect the solution for clarity and particulates, and use aseptic technique to maintain sterility.

Isoplasmal G is administered intravenously, typically via a controlled infusion pump. The infusion rate and total volume are set by the prescribing clinician, and the solution is delivered through a sterile IV line under continuous monitoring for any adverse reactions.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, acute renal impairment, significant electrolyte disturbances, and metabolic acidosis. Prompt recognition and medical intervention are essential if any of these events occur during or after infusion.

Isoplasmal G should be avoided in patients with known hypersensitivity to any of its amino acid components, those with severe renal or hepatic failure where amino acid load is contraindicated, and individuals receiving incompatible intravenous medications without proper line flushing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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