Product image of Isoprenalin Macure (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenalin Macure

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenalin Macure (Isoprenaline Hydrochloride)

Isoprenaline, the active ingredient in Isoprenalin Macure, is a non‑selective beta‑adrenergic agonist presented as an intravenous solution for acute cardiovascular and respiratory use. It is employed to increase heart rate and contractility in bradyarrhythmias, to support cardiac output during heart block or cardiac arrest, and to produce bronchodilation in severe asthma attacks. The drug acts rapidly when administered by infusion and is typically used under close clinical monitoring in hospital settings.

GNH India supplies Isoprenalin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Isoprenalin is used in conditions that require rapid stimulation of beta‑adrenergic receptors to improve cardiac output or airway patency.

  • Bradyarrhythmias: raises heart rate to restore adequate perfusion.
  • Heart block: increases conduction through the AV node to improve rhythm.
  • Cardiac arrest (adjunct): supports circulation while definitive resuscitation measures are applied.
  • Bronchial asthma: relaxes bronchial smooth muscle to relieve acute bronchospasm.

How It Works

  • Isoprenaline hydrochloride binds to both beta‑1 and beta‑2 adrenergic receptors, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP enhances calcium influx in cardiac myocytes, boosting heart rate and contractile force, while in bronchial smooth muscle it promotes relaxation, leading to bronchodilation. The combined beta‑1 and beta‑2 stimulation underlies its cardiac stimulant and bronchodilator actions.

Side Effects

Isoprenalin may cause a range of adverse reactions, from mild to severe, depending on dose and patient sensitivity.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Palpitations: awareness of heart beating.
  • Tremor: fine muscle shaking.
  • Headache: mild to moderate pain.
  • Nausea: feeling of sickness.
  • Hyperglycemia: elevated blood glucose levels.

Serious or Rare Side Effects

  • Arrhythmias: abnormal heart rhythms, including ventricular tachycardia.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Pulmonary edema: fluid accumulation in lungs.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Cardiac arrest: loss of effective heart function.

Precautions & Warnings

Use of Isoprenaline requires careful assessment of cardiovascular and respiratory status.

  • Cardiac monitoring: continuous ECG and blood pressure observation.
  • Dose titration: adjust infusion rate to achieve target heart rate.
  • Contraindications: avoid in patients with severe tachyarrhythmias or uncontrolled hypertension.
  • Caution in diabetes: monitor blood glucose due to possible hyperglycemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Isoprenaline can interact with other agents that affect adrenergic tone or cardiac conduction.

Major Interactions (Avoid)

  • Beta‑blockers: antagonize therapeutic effects and may precipitate severe bradycardia.
  • Calcium channel blockers (verapamil, diltiazem): increase risk of heart block and hypotension.
  • MAO inhibitors: may potentiate hypertensive responses.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate electrolyte disturbances, affecting cardiac rhythm.
  • Antidiabetic drugs: monitor for hyperglycemia.
  • Inhaled bronchodilators: additive bronchodilation may cause tachycardia.
  • Anesthetics: potential for exaggerated cardiovascular responses.

Frequently Asked Questions

Isoprenalin Macure is indicated for acute management of bradyarrhythmias, heart block, as an adjunct in cardiac arrest, and for severe bronchial asthma where rapid bronchodilation is required. It is administered intravenously in hospital settings under physician supervision.

Isoprenaline stimulates both beta‑1 and beta‑2 adrenergic receptors. Activation of beta‑1 receptors increases heart rate and contractility, while beta‑2 activation relaxes bronchial smooth muscle, producing bronchodilation. The combined effect improves cardiac output and airway patency.

The dose of Isoprenalin Macure is individualized by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Dosage regimens are determined in a controlled clinical environment and are not standardized in public information.

Safety data for isoprenaline in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Isoprenaline is a non‑selective beta‑adrenergic agonist, offering both heart rate acceleration and bronchodilation, unlike selective agents such as dobutamine (beta‑1 selective) which lack significant bronchodilator activity. Choice of agent depends on the clinical scenario and desired pharmacologic profile.

Isoprenalin Macure should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Maintain the cold‑chain during transport to preserve stability.

The product is supplied as an intravenous solution and is administered by slow infusion or bolus injection under continuous cardiac and hemodynamic monitoring. Administration techniques follow institutional protocols and the prescribing physician’s instructions.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and allergic reactions such as anaphylaxis. Immediate medical intervention is required if any of these events occur.

Patients with uncontrolled tachyarrhythmias, severe hypertension, known hypersensitivity to isoprenaline, or those taking beta‑blockers without appropriate medical oversight should not receive Isoprenalin Macure. Contraindications are determined by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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