Isoprenalina Labesfal (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride is used in cardiovascular emergencies to stimulate β‑adrenergic receptors and improve cardiac function.

• Bradyarrhythmias: increases heart rate to restore normal rhythm.
• Cardiac arrest: provides β‑adrenergic stimulation to support cardiac output during resuscitation.
• Heart block: enhances atrioventricular conduction to improve heart rhythm.

• Isoprenaline Hydrochloride acts as a non‑selective β‑adrenergic receptor agonist. By binding to β1 and β2 receptors on cardiac myocytes, it increases cyclic AMP levels, leading to enhanced calcium influx, which raises heart rate, myocardial contractility, and conduction velocity, thereby improving cardiac output in acute settings.

Isoprenaline Hydrochloride may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Tachycardia: excessive increase in heart rate.
• Palpitations: sensation of rapid or irregular heartbeat.
• Tremor: involuntary muscle shaking.
• Headache: mild to moderate pain in the head.
• Nausea: feeling of sickness or urge to vomit.
• Hyperglycemia: elevated blood glucose levels.

Serious or Rare Side Effects

• Arrhythmias: potentially dangerous irregular heart rhythms.
• Myocardial ischemia: reduced blood flow to heart muscle.
• Severe hypotension: dangerous drop in blood pressure.
• Pulmonary edema: fluid accumulation in the lungs.
• Allergic reactions: rash, itching, swelling, or anaphylaxis.
• Cardiac arrest: worsening of cardiac function in rare cases.

When using Isoprenaline Hydrochloride, clinicians should observe specific safety measures.

• Cardiac monitoring: continuous ECG to detect arrhythmias.
• Dose titration: adjust dose gradually based on hemodynamic response.
• Contraindications: avoid in patients with severe tachyarrhythmias.
• Drug interactions: review concomitant β‑blocker therapy.
• Pregnancy and lactation: use only if benefits outweigh risks.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Isoprenaline Hydrochloride can interact with several medications, requiring careful management.

Major Interactions (Avoid)

• β‑blockers: may blunt therapeutic effect and cause severe bradycardia.
• Calcium channel blockers: increase risk of hypotension and heart block.
• MAO inhibitors: potentiate cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

• Diuretics: may exacerbate electrolyte disturbances.
• Antihypertensives: require blood pressure monitoring.
• Digitalis glycosides: increase risk of arrhythmias.
• Anesthetics: may enhance cardiac stimulation effects.