Product image of Isoprenalina Phagecon (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenalina Phagecon

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenalina Phagecon (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenalina Phagecon, is a beta‑adrenergic agonist presented as a sterile solution for intravenous use. It is employed to increase heart rate and contractility in patients with symptomatic bradycardia or heart block, and may be used off‑label as a bronchodilator in asthma.

GNH India supplies Isoprenalina Phagecon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Phagecon-Servicos E Consultoria Farmaceutica

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Indications & Clinical Uses

Isoprenaline acts on the cardiovascular and respiratory systems to correct rhythm disturbances and improve airway tone.

  • Symptomatic bradycardia: raises heart rate to relieve dizziness and fatigue.
  • Heart block: enhances atrioventricular conduction to maintain adequate cardiac output.
  • Asthma (off‑label): provides bronchodilation when conventional therapies are insufficient.

How It Works

  • Isoprenaline Hydrochloride non‑selectively stimulates β1 and β2 adrenergic receptors, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP enhances calcium influx in cardiac myocytes, boosting heart rate and contractility, while relaxing bronchial smooth muscle, resulting in bronchodilation.

Side Effects

Isoprenaline may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Tachycardia: rapid heart rate.
  • Palpitations: awareness of heartbeat.
  • Tremor: involuntary shaking.
  • Headache: mild to moderate pain.
  • Anxiety: nervousness or restlessness.
  • Nausea: upset stomach.

Serious or Rare Side Effects

  • Arrhythmias: abnormal heart rhythms.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerously low blood pressure.
  • Bronchospasm: paradoxical airway constriction.
  • Anaphylaxis: severe allergic reaction.
  • Cardiac arrest: sudden loss of heart function.

Precautions & Warnings

Careful monitoring and patient assessment are essential when using Isoprenaline.

  • Cardiovascular monitoring: observe heart rate and rhythm continuously.
  • Dose titration: adjust infusion rate based on clinical response.
  • Contraindications: avoid in patients with uncontrolled tachyarrhythmias.
  • Caution in ischemic heart disease: monitor for chest pain.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Isoprenaline can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Beta‑blockers: antagonize therapeutic effect, may precipitate severe bradycardia.
  • MAO inhibitors: increase risk of hypertensive crisis.
  • Other sympathomimetics: additive cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance negative inotropic effects.
  • Digoxin: risk of arrhythmias.
  • Diuretics: potential electrolyte disturbances affecting cardiac response.
  • Anesthetic agents: may potentiate hemodynamic instability.

Frequently Asked Questions

Isoprenalina Phagecon contains isoprenaline hydrochloride, a beta‑adrenergic agonist administered intravenously to treat symptomatic bradycardia and heart block by increasing heart rate and contractility. It may also be employed off‑label as a bronchodilator in severe asthma when other treatments are inadequate.

Isoprenaline binds to both β1 and β2 adrenergic receptors, activating adenylate cyclase and raising intracellular cyclic AMP levels. In the heart, this enhances calcium influx, speeding up the pacemaker activity and strengthening contractions. In the lungs, β2 stimulation relaxes bronchial smooth muscle, producing bronchodilation.

The dosage of Isoprenalina Phagecon is determined by the prescribing clinician based on the patient’s condition, weight, and response. It is typically administered as an intravenous infusion, with the rate adjusted to achieve the desired heart rate or bronchodilatory effect.

Safety data for isoprenaline in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Isoprenaline is a non‑selective β1/β2 agonist, offering both cardiac stimulation and bronchodilation, whereas agents like albuterol are selective for β2 receptors and primarily used for asthma. Compared with selective agents, isoprenaline has a broader cardiovascular effect, which can be advantageous in bradyarrhythmias but requires careful monitoring for cardiac side effects.

Isoprenalina Phagecon should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed container. Do not freeze the solution. Before use, inspect for particulate matter or discoloration and discard if any abnormalities are observed.

The product is supplied as a sterile injectable solution for intravenous infusion. Administration is performed by qualified healthcare personnel, typically using a calibrated infusion pump to control the delivery rate, with continuous monitoring of cardiac parameters throughout the infusion.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, bronchospasm, and anaphylactic reactions. Immediate medical intervention is required if any of these events occur, and patients should be monitored closely during and after infusion.

Isoprenalina Phagecon is contraindicated in patients with uncontrolled tachyarrhythmias, severe coronary artery disease, or known hypersensitivity to isoprenaline. Caution is also advised for individuals with hypertension, hyperthyroidism, or those taking beta‑blockers, as the drug may produce adverse cardiovascular effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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