Product image of Isoprenaline Chlorhydrate Tillomed (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Chlorhydrate Tillomed

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Chlorhydrate Tillomed (Isoprenaline Hydrochloride)

Isoprenaline, the active ingredient in Isoprenaline Chlorhydrate Tillomed, is a non‑selective beta‑adrenergic agonist presented as a strength/form for intravenous use. It is used to raise heart rate and contractility in bradycardia and to relax bronchial smooth muscle in asthma.
GNH India supplies Isoprenaline Chlorhydrate Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Pharma Gmbh

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Indications & Clinical Uses

Isoprenaline acts on the cardiac and respiratory systems to correct rhythm disturbances and relieve bronchospasm.

  • Bradycardia: increases heart rate and improves cardiac output.
  • Heart block: restores atrioventricular conduction and stabilises rhythm.
  • Asthma: produces bronchodilation that eases bronchospasm and improves airflow.

How It Works

  • Isoprenaline binds to and activates both beta‑1 and beta‑2 adrenergic receptors. Stimulation of beta‑1 receptors in the myocardium raises intracellular cyclic AMP, enhancing calcium influx and thereby increasing heart rate and contractile force. Activation of beta‑2 receptors in bronchial smooth muscle leads to relaxation through a similar cAMP‑mediated pathway, resulting in bronchodilation.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Tachycardia
  • Palpitations
  • Tremor
  • Headache
  • Nausea
  • Flushing

Serious or Rare Side Effects

  • Life‑threatening arrhythmias
  • Myocardial ischemia
  • Severe hypotension
  • Pulmonary edema
  • Anaphylactic or severe allergic reactions
  • Exacerbation of bronchospasm

Precautions & Warnings

Careful assessment and monitoring are required before and during therapy.

  • Cardiac monitoring: observe heart rate, rhythm and blood pressure continuously.
  • Ischemic heart disease: avoid or use only with specialist supervision due to risk of angina.
  • Hypertension: monitor closely as beta‑2 stimulation may increase systolic pressure.
  • Renal or hepatic impairment: adjust dose cautiously and monitor drug levels if available.
  • Pheochromocytoma: contraindicated because of potential hypertensive crisis.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Isoprenaline may interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: antagonise therapeutic effects and may precipitate severe bradycardia.
  • Calcium channel blockers: additive cardiac effects can lead to arrhythmias.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive episodes.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive response.
  • Other antihypertensives: require blood pressure monitoring.
  • General anaesthetics: may enhance cardiovascular depression; adjust dosing as needed.

Frequently Asked Questions

Isoprenaline Chlorhydrate Tillomed is prescribed to treat severe bradycardia, certain types of heart block, and acute bronchospasm such as that seen in asthma. It works by stimulating heart rate and relaxing airway smooth muscle.

Isoprenaline activates beta‑1 receptors in the heart, increasing heart rate and contractility, and beta‑2 receptors in the lungs, causing bronchodilation. Both actions are mediated through a rise in intracellular cyclic AMP.

The dose of Isoprenaline is determined by the prescribing clinician based on the patient’s condition, response, and clinical monitoring. Dosage regimens are individualized and should follow local prescribing guidelines.

Safety data for Isoprenaline in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Isoprenaline is a non‑selective beta‑agonist, offering both heart‑rate acceleration and bronchodilation, unlike selective agents such as dopamine or dobutamine which primarily target cardiac output. Its broader receptor activity can be advantageous in combined cardiac‑respiratory emergencies but may also increase the risk of side effects.

Store at room temperature: keep the product in its original packaging, protect it from moisture and direct light, and avoid freezing. Ensure the container is tightly sealed until use.

The medication is given intravenously under strict medical supervision. It is typically administered as a controlled infusion or bolus, with continuous cardiac and respiratory monitoring throughout the procedure.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to isoprenaline, uncontrolled hypertension, recent myocardial infarction, severe coronary artery disease, pheochromocytoma, or those taking beta‑blockers without appropriate medical oversight should not receive this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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