Product image of Isoprenaline Hcl Macure (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Hcl Macure

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Hcl Macure (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenaline Hcl Macure, is a non‑selective beta‑adrenergic agonist presented as an injectable solution for intravenous administration. It is used to increase heart rate and contractility in symptomatic bradycardia, heart block, cardiogenic shock, and to relax bronchial smooth muscle in asthma or bronchospasm.

GNH India supplies Isoprenaline Hcl Macure as a licensed, GMP‑and GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under regulated quality standards.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Isoprenaline Hydrochloride acts on beta‑adrenergic receptors to provide cardiac stimulation and bronchodilation.

  • Symptomatic bradycardia: increases heart rate to alleviate slow heart rhythms.
  • Heart block: improves atrioventricular conduction and cardiac output.
  • Cardiogenic shock: enhances myocardial contractility and cardiac output during low‑output states.
  • Asthma and bronchospasm: relaxes bronchial smooth muscle to improve airflow.

How It Works

  • Isoprenaline Hydrochloride binds to and activates both β1‑adrenergic receptors in cardiac tissue and β2‑adrenergic receptors in bronchial smooth muscle. Activation stimulates adenylate cyclase, raising intracellular cyclic AMP, which increases calcium influx in cardiac myocytes (producing positive chronotropic and inotropic effects) and causes relaxation of bronchial smooth muscle, resulting in bronchodilation.

Side Effects

Isoprenaline may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tachycardia: rapid heart rate.
  • Palpitations: awareness of heartbeat.
  • Tremor: fine muscle shaking.
  • Headache: mild to moderate headache.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening irregular heart rhythms.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe bronchospasm: paradoxical worsening of airway constriction.

Precautions & Warnings

Use of Isoprenaline requires careful clinical monitoring.

  • Cardiac monitoring: observe heart rate and rhythm during infusion.
  • Hypotension risk: monitor blood pressure, especially in patients with pre‑existing low pressure.
  • Thyroid disease: use cautiously in hyperthyroid patients.
  • Diabetes: beta‑agonist may affect glucose levels.
  • Concomitant MAO inhibitors: increased risk of hypertensive crisis.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Isoprenaline can interact with several drug classes, requiring attention to avoid reduced efficacy or heightened toxicity.

Major Interactions (Avoid)

  • Beta‑blockers: antagonize therapeutic effect, may precipitate severe bradycardia.
  • Monoamine oxidase inhibitors (MAOIs): may cause hypertensive episodes.
  • Digitalis glycosides: increased risk of arrhythmias.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate electrolyte disturbances affecting cardiac response.
  • Anticholinergic agents: may blunt bronchodilatory effect.
  • CYP450 inhibitors: potential alteration of drug clearance, though data are limited.

Frequently Asked Questions

Isoprenaline Hcl Macure is an injectable form of isoprenaline hydrochloride used to increase heart rate and contractility in conditions such as symptomatic bradycardia, heart block and cardiogenic shock, and to provide bronchodilation in asthma or bronchospasm.

Isoprenaline Hydrochloride activates both β1‑adrenergic receptors in the heart and β2‑adrenergic receptors in the airways. This stimulation raises intracellular cyclic AMP, producing a faster, stronger heartbeat and relaxing bronchial smooth muscle, which improves airflow.

The dose of Isoprenaline is individualized and set by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Specific dosing regimens are not provided here.

Safety data for Isoprenaline in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

The primary alternative is epinephrine, which also stimulates adrenergic receptors but has a stronger α‑adrenergic component, leading to more pronounced vasoconstriction. Isoprenaline is more selective for β receptors, offering greater heart‑rate acceleration and bronchodilation with less peripheral vascular effect.

Isoprenaline injection should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Isoprenaline is administered intravenously, either as a slow bolus or continuous infusion, according to the prescriber’s instructions. Administration is performed by qualified healthcare personnel in a setting where cardiac monitoring is available.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypertension, and paradoxical bronchospasm. Immediate medical attention is required if patients develop chest pain, irregular heart rhythm, or worsening respiratory symptoms.

Isoprenaline is contraindicated in patients with severe tachyarrhythmias, uncontrolled hypertension, recent myocardial infarction, or known hypersensitivity to the drug. Caution is also advised in individuals with hyperthyroidism, diabetes, or severe coronary artery disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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