Product image of Isoprenaline Hydrochloride Macure Healthcare (Isoprenaline Hydrochloride) supplied by GNH India

Isoprenaline Hydrochloride Macure Healthcare

Active Ingredient:
Isoprenaline Hydrochloride
Origin:
EU

Isoprenaline Hydrochloride Macure Healthcare (Isoprenaline Hydrochloride)

Isoprenaline Hydrochloride, the active ingredient in Isoprenaline Hydrochloride Macure Healthcare, is a non‑selective beta‑adrenergic agonist presented as a sterile solution for intravenous use. It is employed to raise heart rate in bradycardia, improve conduction in heart block, and relax airway smooth muscle in asthma and bronchospasm.
GNH India supplies Isoprenaline Hydrochloride Macure Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Macure Healthcare Limited

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Indications & Clinical Uses

Isoprenaline Hydrochloride acts on the cardiac and respiratory adrenergic pathways to restore normal rhythm and airway tone.

  • Bradycardia: increases heart rate to alleviate symptomatic slow rhythm.
  • Heart block: enhances atrioventricular conduction to improve cardiac output.
  • Asthma: relaxes bronchial smooth muscle to relieve airway obstruction.
  • Bronchospasm: induces bronchodilation for acute respiratory distress.

How It Works

  • Isoprenaline Hydrochloride stimulates both beta‑1 and beta‑2 adrenergic receptors, activating adenylate cyclase and raising intracellular cyclic AMP. The rise in cAMP enhances calcium influx in cardiac myocytes, increasing heart rate and contractility, while in bronchial smooth muscle it promotes relaxation, resulting in bronchodilation.

Side Effects

Isoprenaline Hydrochloride may cause a range of adverse reactions during intravenous administration.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Palpitations: sensation of irregular or forceful heartbeats.
  • Headache: mild to moderate cranial discomfort.
  • Tremor: fine muscle shaking, especially in the hands.
  • Nausea: feeling of stomach upset.
  • Anxiety: heightened nervousness or restlessness.

Serious or Rare Side Effects

  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Myocardial ischemia: reduced blood flow to heart muscle.
  • Severe hypotension: dangerous drop in blood pressure.
  • Paradoxical bronchospasm: unexpected airway constriction.
  • Anaphylactic reaction: severe allergic response.
  • Cardiac arrest: sudden loss of heart function.

Precautions & Warnings

When using Isoprenaline Hydrochloride, clinicians should observe several safety measures.

  • Cardiac monitoring: continuously assess heart rate and rhythm during infusion.
  • Dose titration: adjust infusion rate gradually to avoid excessive tachycardia.
  • Contraindications: avoid in patients with severe tachyarrhythmias or recent myocardial infarction.
  • Pregnancy: prescribe only if potential benefit justifies potential risk to the fetus.
  • Drug interactions: review concomitant beta‑blocker therapy before administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Isoprenaline Hydrochloride can interact with several cardiovascular and respiratory agents.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may antagonize therapeutic effect.
  • Class IA antiarrhythmics (e.g., quinidine): increase risk of severe arrhythmias.
  • Monoamine oxidase inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: additive cardiac effects requiring monitoring.
  • Diuretics: may exacerbate electrolyte disturbances.
  • Theophylline: heightened risk of tachycardia and arrhythmia.

Frequently Asked Questions

Isoprenaline Hydrochloride is employed to treat symptomatic bradycardia, certain types of heart block, and acute bronchospasm associated with asthma. By stimulating beta‑1 receptors it raises heart rate, and by activating beta‑2 receptors it relaxes airway smooth muscle, providing rapid relief in these clinical situations.

The drug binds to both beta‑1 and beta‑2 adrenergic receptors, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP enhances calcium handling in cardiac cells, boosting heart rate and contractility, while in bronchial smooth muscle it promotes relaxation, leading to bronchodilation.

The specific dose and infusion rate of Isoprenaline Hydrochloride are determined by the prescribing clinician based on the patient’s condition, weight, and response. Dosing is individualized and should follow local clinical guidelines and the prescriber’s judgment.

Safety data for Isoprenaline Hydrochloride in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with selective beta‑1 agonists such as dobutamine, Isoprenaline Hydrochloride activates both beta‑1 and beta‑2 receptors, producing a stronger increase in heart rate and more pronounced bronchodilation. This broader activity can be advantageous in combined cardiac and respiratory emergencies but may also raise the risk of tachyarrhythmias.

The sterile solution should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Maintaining the cold chain preserves potency and prevents degradation of the active ingredient.

Isoprenaline Hydrochloride is supplied as an injectable solution for intravenous infusion. Administration is performed by a qualified healthcare professional, typically using a calibrated infusion pump to allow precise rate adjustments according to the patient’s response.

The most critical adverse events include life‑threatening arrhythmias such as ventricular tachycardia, myocardial ischemia, severe hypotension, paradoxical bronchospasm, and anaphylactic reactions. Continuous cardiac monitoring and readiness to manage these events are essential during therapy.

Patients with uncontrolled tachyarrhythmias, recent myocardial infarction, severe coronary artery disease, or known hypersensitivity to the drug should not be given Isoprenaline Hydrochloride. Contraindications must be evaluated by the prescribing clinician before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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